Performance of Positron Emission Tomography-Computed Tomography and Bone Marrow Biopsy in Detecting Bone Marrow Infiltration in Lymphoma Cases
In: Turkish Journal of Hematology, Jg. 37 (2020), Heft 4, S. 220-225
Online
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Zugriff:
Bone marrow infiltration (BMI) affects the stage diagnosis, and treatment of lymphoma. We aimed to evaluate the performance of bone marrow biopsy (BMB) and positron emission tomography-computed tomography (PET/CT) in detecting BMI in lymphoma patients.A total of 269 non-Hodgkin’s lymphoma (NHL) and 110 Hodgkin’s lymphoma (HL) patients were evaluated retrospectively. Sensitivity, negative predictive value (NPV), and accuracy were calculated for PET/CT and BMB in detecting BMI.ensitivity, negative predictive value (NPV) and accuracy were calculated for PET/CT and BMB in detecting BMI.Sensitivity, NPV, and accuracy for PET/CT in detecting BMI in NHL cases were 65%, 78%, and 84.4%, respectively, while they were 55%, 73.4%, and 79.9% for BMB. PET/CT performance for diffuse large B-cell lymphoma and follicular lymphoma was better than that of BMB, whereas the performance of BMB was better for mantle-cell lymphoma, Burkitt’s lymphoma, and primary mediastinal B-cell lymphoma. Sensitivity, NPV, and accuracy for PET/CT in HL cases were 91.3%, 97.75%, and 98.18%, respectively, while they were 56.52%, 89.69%, and 90.91% for BMB. Due to BMB, 43 (15.9%) patients in the NHL group and 2 (1.8%) patients in the HL group were protected from downstaging.Although their results vary according to NHL subtypes, PET/CT and BMB are complementary methods in determining BMI. In HL, PET/CT is an important diagnostic tool for detecting BMI, and BMB is not necessary in a significant proportion of cases.Kemik iliği infiltrasyonu (Kİİ), lenfoma evresini, sağkalımı ve tedaviyi etkiler. Lenfoma hastalarında Kİİ’yi saptamada kemik iliği biyopsisi (KİB) ve pozitron emisyon tomografi-bilgisayarlı tomografinin (PET/BT) performanslarını değerlendirmek istedik.İki yüz altmış dokuz non-Hodgkin lenfoma (NHL) ve 110 hodgkin lenfoma (HL) hastası retrospektif olarak değerlendirildi. Kİİ’yi saptamada PET/BT ve KİB için duyarlılık, negatif prediktif değer (NPD) ve doğruluk hesaplandı.NHL olgularında Kİİ’yi saptamada PET/BT için duyarlılık, NPD ve doğruluk sırasıyla %65, %78 ve %84,4 iken KİB için %55, %73,4 ve %79,9 idi. Diffüz büyük B-hücreli lenfoma ve folliküler lenfoma için PET/BT performansı KİB’den daha iyi iken; mantle-cell lenfoma, Burkitt’s lenfoma ve primer mediastinal B-hücreli lenfomada KİB performansı daha iyiydi. HL olgularında PET/BT için duyarlılık, NPD ve doğruluk sırasıyla %91,3, %97,75 ve %98,18 iken KİB için %56,52, %89,69 ve %90,91 idi. KİB yapılması ile NHL grubunda 43 (%15,9), HL grubunda ise 2 (%1,8) olgunun düşük evrelenmesinden korunmuş olundu.Kİİ’yi saptamada NHL alt tiplerine göre değişmekle birlikte PET/BT ve KİB birbirini tamamlayıcı yöntemlerdir. HL’de ise Kİİ’yi saptamak için PET/BT önemli bir tanı aracıdır ve KİB olguların önemli kısmında gerekli değildir.
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Performance of Positron Emission Tomography-Computed Tomography and Bone Marrow Biopsy in Detecting Bone Marrow Infiltration in Lymphoma Cases
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Autor/in / Beteiligte Person: | Isa Burak Guney ; Büyükşimşek, Mahmut ; Abdullah Evren Yetisir ; Mirili, Cem ; Kolsuz, İrem ; Ogul, Ali ; Paydas, Semra ; Tohumcuoglu, Mert |
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Zeitschrift: | Turkish Journal of Hematology, Jg. 37 (2020), Heft 4, S. 220-225 |
Veröffentlichung: | Galenos Yayinevi, 2020 |
Medientyp: | unknown |
ISSN: | 1308-5263 (print) ; 1300-7777 (print) |
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