Anti-platelet activating factor (PAF) antibody inhibits CFW mouse preimplantation embryo development
In: Journal of Assisted Reproduction and Genetics, Jg. 11 (1994-09-01), S. 414-418
Online
unknown
Zugriff:
Our purpose was to investigate the effect of anti-PAF antibodies on CFW mouse embryo development in vitro.We studied the in vitro development of CFW mouse one-cell-stage embryos cultured in MEM supplemented with anti-PAF, anti-IgG, or MEM alone to the hatched blastocyst stage.Mouse embryos cultured with anti-PAF (1:5 dilution; 61%) significantly decreased embryo development compared to controls (MEM alone; 93%), whereas embryos cultured in anti-mouse IgG-supplemented MEM (1:10 dilution; 93%) had no effect.The results provide additional evidence that PAF is produced and secreted by cleavage-stage embryos and is required during the preimplantation period.
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Anti-platelet activating factor (PAF) antibody inhibits CFW mouse preimplantation embryo development
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Autor/in / Beteiligte Person: | Butler, William J. ; Mathur, Subbi ; Roudebush, William E. |
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Zeitschrift: | Journal of Assisted Reproduction and Genetics, Jg. 11 (1994-09-01), S. 414-418 |
Veröffentlichung: | Springer Science and Business Media LLC, 1994 |
Medientyp: | unknown |
ISSN: | 1573-7330 (print) ; 1058-0468 (print) |
DOI: | 10.1007/bf02211729 |
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