Urinary proteome analysis identifies infants but not older children requiring pyeloplasty
In: Pediatric Nephrology Pediatric Nephrology, 2010, epub ahead of print. ⟨10.1007/s00467-010-1455-8⟩ Pediatric Nephrology, Springer Verlag, 2010, epub ahead of print. ⟨10.1007/s00467-010-1455-8⟩; (2010)
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International audience; One out of every five children suffering from ureteropelvic junction obstruction (UPJO) requires pyeloplasty. This prevalence indicates an urgent necessity to identify high-grade UPJO as early as possible to avoid renal damage. A novel non-invasive proteomic urine test has recently been introduced that is able to detect these patients at an early stage. In the study reported here, we tested this approach to assess its use in our centre and to expand its application to older children. Twenty-seven children (median age 0.4 years, range 0.1-8.8 years) with hydronephrosis who had been scheduled a nuclear diuretic renal scan (DR) to identify urodynamically relevant UPJO were included in our prospective study. Patients with prior surgery of the urinary tract were excluded. The urinary proteome pattern was analysed using capillary electrophoresis coupled to mass spectrometry. Of the 27 children, 11 had a relevant UPJO diagnosed by the DR. In 19 children
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Urinary proteome analysis identifies infants but not older children requiring pyeloplasty
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Autor/in / Beteiligte Person: | Schanstra, Joost P. ; Pape, Lars ; Ehrich, Jochen H. H. ; Schiffer, Eric ; Bascands, Jean-Loup ; Kirschstein, Martin ; Ure, Benno M. ; Glüer, Sylvia ; Drube, Jens ; Mischak, Harald ; Decramer, Stéphane ; Lau, Esther ; Zürbig, Petra ; Simon, Marie Francoise ; Department of Pediatric Kidney ; Hannover Medical School [Hannover] (MHH)-Children's Hospital ; Mosaiques Diagnostics GmbH ; Center of Pediatric Surgery Hannover ; site, Bult ; Hannover Medical School [Hannover] (MHH) ; Department, Pediatric ; Celle General Hospital-Teaching Hospital of Hannover Medical School ; Institut de médecine moléculaire de Rangueil (I2MR) ; Université Toulouse III - Paul Sabatier (UT3) ; Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM) |
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Quelle: | Pediatric Nephrology Pediatric Nephrology, 2010, epub ahead of print. ⟨10.1007/s00467-010-1455-8⟩ Pediatric Nephrology, Springer Verlag, 2010, epub ahead of print. ⟨10.1007/s00467-010-1455-8⟩; (2010) |
Veröffentlichung: | HAL CCSD, 2010 |
Medientyp: | unknown |
ISSN: | 0931-041X (print) ; 1432-198X (print) |
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