Dendrimer-protein interactions versus dendrimer-based nanomedicine
In: Colloids and Surfaces B: Biointerfaces Colloids and Surfaces B: Biointerfaces, Elsevier, 2017, 152, pp.414-422. ⟨10.1016/j.colsurfb.2017.01.041⟩; (2017-01-31)
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Zugriff:
Dendrimers are hyperbranched polymers belonging to the huge class of nanomedical devices. Their wide application in biology and medicine requires understanding of the fundamental mechanisms of their interactions with biological systems. Summarizing, electrostatic force plays the predominant role in dendrimer-protein interactions, especially with charged dendrimers. Other kinds of interactions have been proven, such as H-bonding, van der Waals forces, and even hydrophobic interactions. These interactions depend on the characteristics of both participants: flexibility and surface charge of a dendrimer, rigidity of protein structure and the localization of charged amino acids at its surface. pH and ionic strength of solutions can significantly modulate interactions. Ligands and cofactors attached to a protein can also change dendrimer-protein interactions. Binding of dendrimers to a protein can change its secondary structure, conformation, intramolecular mobility and functional activity. However, this strongly depends on rigidityversusflexibility of a protein’s structure. In addition, the potential applications of dendrimers to nanomedicine are reviwed related to dendrimer-protein interactions.
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Dendrimer-protein interactions versus dendrimer-based nanomedicine
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| Autor/in / Beteiligte Person: | Pedziwiatr-Werbicka, Elzbieta ; Ionov, Maksim ; Majoral, Jean-Pierre ; María Ángeles Muñoz-Fernández ; Bryszewska, Maria ; Dzmitruk, Volha ; Shcharbin, Dzmitry ; Shcharbina, Natallia ; Mignani, Serge ; F. Javier de la Mata ; Gómez, Rafael ; Institute of Biophysics and Cell Engineering, NASB, Minsk ; National Academy of Sciences of Belarus (NASB) ; Clinics at the MAZ Company, Minsk ; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz ; University of Lódź ; Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601) ; Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS) ; Université Paris Descartes - Paris 5 (UPD5) ; Université Sorbonne Paris Cité (USPC) ; Departamento Química Orgánica y Química Inorgánica, Universidad de Alcalá, Alcalá de Henares ; Universidad de Alcalá - University of Alcalá (UAH) ; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) ; Instituto de Salud Carlos III (ISC)-ministerio de ciencia e innovacion ; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM) ; Spanish HIV-HGM BioBank (SHIVBB) ; Virtual Institute on Poverty Related Diseases ; Laboratoire de chimie de coordination (LCC) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3) ; Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599) ; Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3) ; Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) ; Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) ; Instituto de Salud Carlos III [Madrid] (ISC)-ministerio de ciencia e innovacion ; Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3) ; Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
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| Quelle: | Colloids and Surfaces B: Biointerfaces Colloids and Surfaces B: Biointerfaces, Elsevier, 2017, 152, pp.414-422. ⟨10.1016/j.colsurfb.2017.01.041⟩; (2017-01-31) |
| Veröffentlichung: | Zenodo, 2017 |
| Medientyp: | unknown |
| ISSN: | 0927-7765 (print) |
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