Immune Compromise in the Elderly
In: Stiehm's Immune Deficiencies ISBN: 9780128167687; (2014)
Online
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Zugriff:
Infectious disease in elderly people is both more frequent and more severe than in younger adults, and the efficacy of prophylactic vaccination is commonly decreased. The elderly are particularly susceptible to newly emerging or newly encountered pathogens, but persistent herpesviruses such as varicella zoster (VZV) and cytomegalovirus (CMV) also reactivate more frequently than in the young. These observations suggest some degree of immune compromise which may be reflected in the distribution of immune cells and antibodies in the peripheral blood. There is a great deal of heterogeneity in disease susceptibility and response to vaccination in humans, and therefore it would be useful to establish sets of immune biomarkers that reflect immune competence of the individual in this context. The use of such “immune signatures” to predict responsiveness to vaccination and susceptibility to infectious disease would allow better selection of prophylaxis and treatment options in the elderly.
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Immune Compromise in the Elderly
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Autor/in / Beteiligte Person: | Pawelec, Graham ; Müller, Ludmila |
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Quelle: | Stiehm's Immune Deficiencies ISBN: 9780128167687; (2014) |
Veröffentlichung: | Elsevier, 2014 |
Medientyp: | unknown |
ISBN: | 978-0-12-816768-7 (print) |
DOI: | 10.1016/b978-0-12-405546-9.00042-x |
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