Protocatechuic acid (PCA) induced a better antiviral effect by immune enhancement in SPF chickens
In: Microbial Pathogenesis, Jg. 114 (2018), S. 233-238
Online
unknown
Zugriff:
Protocatechuic acid (PCA) is an antiviral agent against Avian Influenza virus (AIV) and Infectious Bursal Disease (IBD) virus , but its antiviral mechanism is unknown. In this study, we evaluated the humoral and cellular responses to PCA in specific pathogen-free (SPF) chickens. One hundred forty 35-day-old SPF chickens were randomly divided into 7 groups. The birds were inoculated with the commercial, attenuated Newcastle Disease Virus (NDV) vaccine and then received orally with 10, 20 or 40 mg/kg body weight of PCA for 30 days. Immune organ indexes, anti-Newcastle Disease Virus (NDV) antibodies and lymphocyte proliferation, but not body weight, were significantly increased in chicken treated with 40 mg/kg PCA, compared to the control birds treated with Astragalus polysaccharide (ASP). Survival rate was 70% and 60%, respectively, in the chickens with 40 mg/kg PCA, 20 mg/kg PCA while 50% survival was found in the birds treated with 125 mg/kg ASP. PCA treatment resulted in significantly lower viral load and reduced shedding. These results indicate that PCA may improve poultry health by enhancing both the humoral and cellular immune response.
Titel: |
Protocatechuic acid (PCA) induced a better antiviral effect by immune enhancement in SPF chickens
|
---|---|
Autor/in / Beteiligte Person: | M. Tariq Javed ; Chu, Jun ; He, Cheng ; Guo, Yongxia ; Xiao, Hongzhi ; Zhang, Qiang ; Zuo, Zonghui |
Link: | |
Zeitschrift: | Microbial Pathogenesis, Jg. 114 (2018), S. 233-238 |
Veröffentlichung: | Elsevier BV, 2018 |
Medientyp: | unknown |
ISSN: | 0882-4010 (print) |
DOI: | 10.1016/j.micpath.2017.11.068 |
Schlagwort: |
|
Sonstiges: |
|