Clinical characteristics and short-term prognosis of in-patients with diabetes and COVID-19: A retrospective study from an academic center in Belgium
In: Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Jg. 15 (2021), S. 149-157
Online
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Zugriff:
Background and aims We describe the characteristics and short-term prognosis of in-patients with diabetes and COVID-19 admitted to a Belgian academic care center. Methods We retrospectively reviewed the data on admission from patients with known or newly-diagnosed diabetes and confirmed COVID-19. First, survivors were compared to non-survivors to study the predictive factors of in-hospital death in patients with diabetes. Secondly, diabetic patients with SARS-CoV-2 pneumonia were matched for age and sex with non-diabetic patients with SARS-CoV-2 pneumonia, to study the prognosis and predictive factors of in-hospital death related to diabetes. Results Seventy-three diabetic patients were included. Mean age was 69 (±14) years. Women accounted for 52%. Most patients had type 2 diabetes (89.0%), long-term complications of hyperglycemia (59.1%), and hypertension (80.8%). The case-fatality rate (CFR) was 15%. Non-survivors had more severe pneumonia based on imaging (p 0.029) and were less often treated with metformin (p 0.036). In patients with SARS-CoV-2 pneumonia, CFR was 15.6% in diabetic (n = 64) and 25.0% in non-diabetic patients (n = 128), the difference being non-significant (p 0.194). Predictive factors of in-hospital death were elevated white blood cells count (HR 9.4, CI 1.50–58.8, p 0.016) and severe pneumonia on imaging (HR 25.0, CI 1.34–466, p 0.031) in diabetic patients, and cognitive impairment (HR 5.80, CI 1.61–20.9, p 0.007) and cardiovascular disease (HR 5.63, CI 1.54–20.6, p 0.009) in non-diabetic patients. Conclusion In this monocentric cohort from Belgium, diabetic in-patients with COVID-19 had mostly type 2 diabetes, prevalent hyperglycemia-related vascular complications and comorbidities including hypertension. In this cohort, the CFR was not statistically different between patients with and without diabetes.
Highlights • Obesity concerns half of the patients with diabetes and COVID-19. • Body mass index and HbA1c do not influence mortality. • Severe pneumonia on imaging predicts death in patients with diabetes and COVID-19. • Case fatality rate was similar in patients with and without diabetes.
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Clinical characteristics and short-term prognosis of in-patients with diabetes and COVID-19: A retrospective study from an academic center in Belgium
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Autor/in / Beteiligte Person: | Hermans, Michel P. ; Vandeleene, Bernard ; Servais, Thomas ; Orioli, Laura ; Thissen, Jean-Paul ; Belkhir, Leila ; Laterre, Pierre-François ; Maiter, Dominique ; Jean Cyr Yombi ; UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition ; UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology ; UCL - SSS/IREC/MEDA - Pôle de médecine aiguë ; UCL - SSS/IREC/SLUC - Pôle St.-Luc ; UCL - (SLuc) Service de soins intensifs ; UCL - (SLuc) Service d'endocrinologie et de nutrition ; UCL - (SLuc) Service de médecine interne générale |
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Zeitschrift: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Jg. 15 (2021), S. 149-157 |
Veröffentlichung: | Elsevier BV, 2021 |
Medientyp: | unknown |
ISSN: | 1871-4021 (print) |
DOI: | 10.1016/j.dsx.2020.12.020 |
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