Keytone metabolism in brain slices from rats with diet induced hyperketonemia
In: The Journal of nutrition, Jg. 108 (1978-04-01), Heft 4
Online
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Zugriff:
The inducibility of ketone body utilization in brain was investigated in vitro in rats fed for 21 days three diets of varying keto- genicity: a nonketogenic low-fat diet (St. diet), a moderately ketogenic high corn oil diet (LCT diet), and a highly ketogenic high medium chain triglycA©ride diet (MCT diet). The protein :energy ratio was the same for all the diets. Total blood ketone body concentrations were 0.19 mM, 0.35 mM, and 0.94 mM in St., LCT, and MCT diets respectively. In brain slices the uptake (50 ^moles/g/2 hours) and metabolism of (U-14C)glucose (40% in lactate, 30% in CO2 and less than 2% into lipids and glycogen) were independent of the diets. Addition of 10 mM cold DL/Miydroxybutyrate decreased by 30% glucose uptake and by 50% the labelling of CO2 and fatty acids, while increasing lactate release, regardless of the nature of the diet. The uptake (20 /unoles/g/2 hours) and conversion of AŸ-hydroxy (3-MC)butyrate into CO2 (40%) and lipids (
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Keytone metabolism in brain slices from rats with diet induced hyperketonemia
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Autor/in / Beteiligte Person: | Hashim, Sami A. ; Lavau, Marcelle M. ; Fornari, Victor |
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Zeitschrift: | The Journal of nutrition, Jg. 108 (1978-04-01), Heft 4 |
Veröffentlichung: | 1978 |
Medientyp: | unknown |
ISSN: | 0022-3166 (print) |
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