An Open-Label Study of Levetiracetam for the Treatment of Social Anxiety Disorder
In: The Journal of Clinical Psychiatry, Jg. 65 (2004-09-15), S. 1219-1222
Online
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Zugriff:
OBJECTIVE Social anxiety disorder is a disabling condition characterized by excessive fear and avoidance of social and performance situations. While a variety of effective pharmacotherapies exists, many patients do not fully respond to or tolerate available agents. Preclinical and early clinical experience with levetiracetam, a novel anticonvulsant agent, suggests that levetiracetam has anxiolytic properties and a favorable adverse event profile. Levetiracetam thus warrants systematic evaluation as a treatment option for anxiety disorders. METHOD Twenty adult outpatients who were recruited through advertisement and clinical referral and who met DSM-IV criteria for social anxiety disorder, generalized type, participated in this 8-week open-label, flexible-dose study from November 2002 to December 2003. Participants were required to have scores of >/= 50 on the Liebowitz Social Anxiety Scale (LSAS) and >/= 4 on the Clinical Global Impressions-Severity of Illness scale (CGI-S) at baseline. The presence of comorbid depression and anxiety disorders were permitted as long as social anxiety disorder was the primary disorder. Levetiracetam was initiated at 250 mg/day for the first week and flexibly titrated up to a maximum of 3000 mg/day (1500 mg b.i.d.). The primary outcome measure was change in the LSAS score at endpoint. RESULTS There was a clinically significant 20.5-point decrease in LSAS scores in the intent-to-treat, last-observation-carried-forward analysis (t = 3.1; p
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An Open-Label Study of Levetiracetam for the Treatment of Social Anxiety Disorder
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Autor/in / Beteiligte Person: | Doyle, Alicia C. ; Link, Nathaniel ; Worthington, John J. ; Pollack, Mark H. ; Simon, Naomi M. ; Kinrys, Gustavo ; Hoge, Elizabeth A. ; Fischmann, Diana |
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Zeitschrift: | The Journal of Clinical Psychiatry, Jg. 65 (2004-09-15), S. 1219-1222 |
Veröffentlichung: | Physicians Postgraduate Press, Inc, 2004 |
Medientyp: | unknown |
ISSN: | 0160-6689 (print) |
DOI: | 10.4088/jcp.v65n0909 |
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