Early reconstitution of effector memory CD4+ CMV-specific T cells protects against CMV reactivation following allogeneic SCT
In: Bone Marrow Transplantation, Jg. 43 (2008-12-22), S. 853-861
Online
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Zugriff:
Reactivation of CMV is a common complication following allogeneic haematopoietic SCT and is associated with significant morbidity and mortality. The relative importance of the CD4+ and CD8+ components of the CMV-specific immune response in protection from reactivation is unclear. The CMV-specific CD4+ and CD8+ immune response was measured at serial time points in 32 patients following allogeneic HSCT. Intracellular cytokine staining following CMV lysate stimulation and HLA-peptide tetramers were used to determine CMV-specific CD4+ and CD8+ responses, respectively. A deficient CMV-specific CD4+ T-cell immune response within the first 30-50 days post transplant was associated with high risk of viral reactivation. Patients with combined impairment of the CD4+ and CD8+ immune response within the first 100 days were susceptible to late viral reactivation. The frequency of CMV-specific CD4+ T cells correlated with CMV-specific CD8+ T cells, comprising 10% of the whole T-cell repertoire. Early CMV-specific CD4+ T-cell reconstitution was dominated by effector memory cells with normal levels of IL-2 resuming 6 months following transplantation. In summary, both CD4 and CD8 CMV-specific immune reconstitution is required for protection from recurrent activation. Measurement of the magnitude of the CMV-specific CD4+ immune response is useful in managing viral reactivation following HSCT.
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Early reconstitution of effector memory CD4+ CMV-specific T cells protects against CMV reactivation following allogeneic SCT
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Autor/in / Beteiligte Person: | Craddock, Charles ; Clark, Fiona ; Bruton, Rachel ; McLarnon, Andrew ; Moss, Paul ; Pourgheysari, Batoul ; Mahendra, Premini ; Cook, Mark ; Piper, Kp. ; Arrazi, Julie |
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Zeitschrift: | Bone Marrow Transplantation, Jg. 43 (2008-12-22), S. 853-861 |
Veröffentlichung: | Springer Science and Business Media LLC, 2008 |
Medientyp: | unknown |
ISSN: | 1476-5365 (print) ; 0268-3369 (print) |
DOI: | 10.1038/bmt.2008.403 |
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