Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP
In: Molecular Brain Research, Jg. 130 (2004-11-01), S. 16-22
Online
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Zugriff:
The immediate early gene c-fos is part of the AP-1 transcription factor complex, which is involved in molecular mechanisms underlying learning and memory. Mice that lack c-Fos in the brain show impairments in spatial reference and contextual learning, and also exhibit a reduced long-term potentiation of synaptic transmission (LTP) at CA3-to-CA1 synapses. In the present study, we investigated mice in which c-fos was deleted and replaced by fra-1 (c-fos(fra-1) mice) to determine whether other members of the c-fos gene family can substitute for the functions of the c-fos gene. In c-fos(fra-1) mice, both CA3-to-CA1 LTP and contextual learning in a Pavlovian fear conditioning task were similar to wild-type littermates, indicating that Fra-1 expression restored the impairments caused by brain-specific c-Fos depletion. However, c-Fos-mediated learning deficits in a reference memory task of the Morris watermaze were also present in c-fos(fra-1) mice. These findings suggest that different c-Fos target genes are involved in LTP, contextual learning, and spatial reference memory formation.
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Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP
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Autor/in / Beteiligte Person: | Strekalova, Tatyana ; Jensen, Vidar ; Wagner, Erwin F. ; Zacher, Christiane ; Gass, Peter ; Fleischmann, Alexander ; Hvalby, Øivind ; Kvello, Ane ; Sprengel, Rolf |
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Zeitschrift: | Molecular Brain Research, Jg. 130 (2004-11-01), S. 16-22 |
Veröffentlichung: | Elsevier BV, 2004 |
Medientyp: | unknown |
ISSN: | 0169-328X (print) |
DOI: | 10.1016/j.molbrainres.2004.07.004 |
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