Altered neural basis of self-reflective processing in schizophrenia: An fMRI study
In: Asian Journal of Psychiatry, Jg. 45 (2019-10-01), S. 53-60
Online
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Background Impaired self-awareness has often been described in schizophrenia. Recent neuroimaging studies examining the self-reflection processes in schizophrenia have produced inconsistent results. Method We examined the self-reflective neural network using self- and other-evaluation tasks in schizophrenia. Fifteen schizophrenia patients and fifteen age- and sex-matched healthy subjects underwent functional magnetic resonance imaging. Subjects were required to decide whether the sentence described their own personal trait (self-evaluation) and that of their close friends (other-evaluation). Results Unlike normal control subjects, the schizophrenia patients did not have greater activation of the left posterior cingulate gyrus and hippocampus during self-evaluation than during other-evaluation. On the other hand, the schizophrenia patients had higher activation of the right superior frontal and right supramarginal gyri during self-evaluation than control subjects. Only the patient group exhibited hyperactivation in the left hippocampus and right external capsule associated with the other-evaluation task. Conclusions These findings provide evidence for an altered neural basis of self-reflective processing, which may underlie the self-awareness deficits in schizophrenia.
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Altered neural basis of self-reflective processing in schizophrenia: An fMRI study
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Autor/in / Beteiligte Person: | Tanino, Ryoichiro ; Furuichi, Atsushi ; Kawasaki, Yasuhiro ; Nakamura, Kazue ; Suzuki, Michio ; Noguchi, Kyo ; Kurachi, Masayoshi ; Takahashi, Tsutomu |
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Zeitschrift: | Asian Journal of Psychiatry, Jg. 45 (2019-10-01), S. 53-60 |
Veröffentlichung: | Elsevier BV, 2019 |
Medientyp: | unknown |
ISSN: | 1876-2018 (print) |
DOI: | 10.1016/j.ajp.2019.08.007 |
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