Quantitative magnetic resonance imaging evidence for altered structural remodeling of the temporal lobe in West syndrome
In: Epilepsia, Jg. 56 (2015-03-02), S. 608-616
Online
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Summary Objective To explore the structure–function relation of the temporal lobe in newly diagnosed West syndrome of unknown cause (uWS). Methods Quantitative magnetic resonance imaging (three-dimensional [3D] structural MRI and diffusion tensor imaging [DTI]) was analyzed using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) in 22 patients and healthy age-matched controls. The electrophysiologic responsiveness of the temporal lobe was measured using the N100 auditory event-related potential (aERP) to a repeated 1,000 Hz tone. Neurocognitive function was assessed using the Bayley Scales of Infant Development, Second Edition (BSID-II). Tests followed first-line treatment with vigabatrin (17 patients) or high-dose oral prednisolone (5 patients). Results Total temporal lobe volume was similar in patients and controls. Patients had a smaller temporal stem (TS) (p
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Quantitative magnetic resonance imaging evidence for altered structural remodeling of the temporal lobe in West syndrome
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Autor/in / Beteiligte Person: | Scott, Rod C. ; Neville, Brian G. R. ; Fosi, T. ; Boyd, Stewart ; Chu, Carlton ; Clark, Chris A. ; Michelle de Haan ; Wui Khean Chong |
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Zeitschrift: | Epilepsia, Jg. 56 (2015-03-02), S. 608-616 |
Veröffentlichung: | Wiley, 2015 |
Medientyp: | unknown |
ISSN: | 0013-9580 (print) |
DOI: | 10.1111/epi.12907 |
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