Thrombopoietin stimulates VEGF release from c-Mpl-expressing cell lines and haematopoietic progenitors
In: FEBS Letters, Jg. 423 (1998-02-13), S. 10-14
Online
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Zugriff:
Vascular endothelial growth factor (VEGF) production was analysed in megakaryocytic cell lines and CD34+ haematopoietic progenitors following treatment with thrombopoietin (TPO). In CMK cells TPO caused a time- and dose-dependent increase in the levels of VEGF released into the medium. A similar effect was observed in UT-7/mpl cells transfected with the TPO receptor c-Mpl, but not in parental UT-7 cells. In CD34+ haematopoietic progenitor cell cultures TPO stimulated VEGF mRNA expression and VEGF protein release. Production of VEGF in CD34+ cultures increased with TPO-induced megakaryocytic differentiation, but not with erythroid or myelomonocytic differentiation induced respectively by erythropoietin and granulocyte-macrophage colony-stimulating factor. These results demonstrate that TPO stimulates VEGF release in c-Mpl-expressing cells and suggest that this process is an integral feature of the megakaryocytic differentiation programme.
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Thrombopoietin stimulates VEGF release from c-Mpl-expressing cell lines and haematopoietic progenitors
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Autor/in / Beteiligte Person: | Breier, Georg ; Erusalimsky, Jorge D. ; Bobik, Renata ; Martin, John ; Hong, Ying |
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Zeitschrift: | FEBS Letters, Jg. 423 (1998-02-13), S. 10-14 |
Veröffentlichung: | Wiley, 1998 |
Medientyp: | unknown |
ISSN: | 0014-5793 (print) |
DOI: | 10.1016/s0014-5793(98)00056-8 |
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