Genetic and environmental regulation of inflammatory CVD biomarkers Lp-PLA2 and IgM anti-PC

Magnusson, Patrik K. E. ; Atout, Rajai ; et al.

In: Atherosclerosis, Jg. 218 (2011-09-01), S. 117-122

Online unknown

Zugriff:

Objective We set out to investigate the relative contribution of genetic and environmental effect on two inflammatory CVD biomarkers; lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) and anti-phosphorylcholine IgM (anti-PC). Their relationships and possible co-regulation with other established CVD biomarkers are also examined. Methods Lp-PLA 2 activity ( N = 1600) and anti-PC ( N = 2036) levels were measured in elderly Swedish twins. Correlation analyses and heritability estimation were conducted by structural equation modeling. Results We attribute 0.37 of the variance of Lp-PLA 2 and 0.40 of anti-PC variance to genetic variance. In addition, a bivariate heritability of 0.33, 0.35 and 0.36 could be detected for levels of Lp-PLA 2 together with ApoB, total cholesterol and LDL, respectively. Anti-PC was only weakly related to other biomarkers of CVD, which may suggest a more independent role of anti-PC as a biomarker. Conclusions In this large sample, Lp-PLA 2 activity has lower heritability and higher environmental regulation than previously reported. Anti-PC levels are partly influenced by dominance genetics and appear to be regulated independently of more established CVD biomarkers.

Titel:	Genetic and environmental regulation of inflammatory CVD biomarkers Lp-PLA2 and IgM anti-PC
Autor/in / Beteiligte Person:	Magnusson, Patrik K. E. ; Atout, Rajai ; Frostegård, Johan ; Rahman, Iffat ; Pedersen, Nancy L. ; Ninio, Ewa ; Ulf de Faire ; Bennet, Anna M.
Link:	View record in OpenAIRE (Volltext) E-Journal im Bestand der UB Hagen? https://doi.org/10.1016/j.atherosclerosis.2011.04.038
Zeitschrift:	Atherosclerosis, Jg. 218 (2011-09-01), S. 117-122
Veröffentlichung:	Elsevier BV, 2011
Medientyp:	unknown
ISSN:	0021-9150 (print)
DOI:	10.1016/j.atherosclerosis.2011.04.038
Schlagwort:	Male medicine.medical_specialty Apolipoprotein B Phosphorylcholine Environment Correlation Internal medicine Genetic variation Diseases in Twins medicine Humans Genetic Predisposition to Disease Aged Inflammation Sweden Genetics Models, Genetic biology Genetic Variation Middle Aged Heritability Large sample Environmental effect Endocrinology Immunoglobulin M Cardiovascular Diseases 1-Alkyl-2-acetylglycerophosphocholine Esterase biology.protein Biomarker (medicine) Female lipids (amino acids, peptides, and proteins) Environmental regulation Cardiology and Cardiovascular Medicine Biomarkers
Sonstiges:	Nachgewiesen in: OpenAIRE Rights: CLOSED

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