Household environmental microbiota influences early‐life eczema development
In: Environmental Microbiology, Jg. 23 (2021-08-12), S. 7710-7722
Online
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Zugriff:
Exposure to a diverse microbial environment during pregnancy and early postnatal period is important in determining predisposition towards allergy. However, the effect of environmental microbiota exposure on allergy during preconception, pregnancy and postnatal life on development of allergy in the child has not been investigated so far. In the S-PRESTO (Singapore PREconception Study of long Term maternal and child Outcomes) cohort, we collected house dust during all three critical window periods and analysed microbial composition using 16S rRNA gene sequencing. At 6 and 18 months, the child was assessed for eczema by clinicians. In the eczema group, household environmental microbiota was characterized by presence of human-associated bacteria Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium at all time points, suggesting their possible contributions to regulating host immunity and increasing the susceptibility to eczema. In the home environment of the control group, putative protective effect of an environmental microbe Planomicrobium (Planococcaceae family) was observed to be significantly higher than that in the eczema group. Network correlation analysis demonstrated inverse relationships between beneficial Planomicrobium and human associated bacteria (Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium). Exposure to natural environmental microbiota may be beneficial to modulate shed human associated microbiota in an indoor environment.
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Household environmental microbiota influences early‐life eczema development
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Autor/in / Beteiligte Person: | Atiqa Binte Zulkifli ; Elizabeth Huiwen Tham ; Evelyn Xiu Ling Loo ; Hui Xing Lau ; Carina Jing Xuan Tay ; Knol, Jan ; Zai Ru Cheng ; Godfrey, Keith M. ; Anne Eng Neo Goh ; Kok Hian Tan ; Eliza Xin Pei Ho ; Gaik Chin Yap ; Le Duc Huy Ta ; Michelle Jia Yu Tay ; Paola Florez de Sessions ; Bee Wah Lee ; Gluckman, Peter D. ; Lay, Christophe ; Lynette Pei-Chi Shek ; Kok Wee Chong ; Jerry Kok Yen Chan ; Si Hui Goh ; Yap Seng Chong ; Cheryl Pei‐Ting Tan ; Eriksson, Johan G. |
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Zeitschrift: | Environmental Microbiology, Jg. 23 (2021-08-12), S. 7710-7722 |
Veröffentlichung: | Wiley, 2021 |
Medientyp: | unknown |
ISSN: | 1462-2920 (print) ; 1462-2912 (print) |
DOI: | 10.1111/1462-2920.15684 |
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