CLR 125 Auger Electrons for the Targeted Radiotherapy of Triple-Negative Breast Cancer
In: Cancer Biotherapy and Radiopharmaceuticals, Jg. 33 (2018-04-01), S. 87-95
Online
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Zugriff:
Purpose: Auger electrons emitted by radioisotopes such as (125)I have a high linear energy transfer and short mean-free path in tissue (95% radiochemical purity was established. To estimate CLR 125 in vivo dosimetry and identify dose-limiting organs, the biodistribution of the analog compound (124)I-CLR1404 (CLR 124) was investigated using micro-positron emission tomography (PET)/computed tomography (CT) in conjunction with a Monte Carlo dosimetry platform to estimate CLR 125 dosimetry. In vivo antitumor efficacy was tested by injecting nude mice bearing either MDA-MB-231-luc orthotopic xenografts or lung metastases with 74 MBq (3.7 GBq/kg) of CLR 125 or an equivalent mass amount of nonradiolabeled CLR 125. Longitudinal tumor measurements using calipers and bioluminescence imaging were obtained for the xenografts and lung metastases, respectively. Results: Dosimetry analysis estimated that CLR 125 would impart the largest absorbed dose to the tumor per injected activity (0.261 ± 0.023 Gy/MBq) while the bone marrow, which is generally the dose-limiting organ for CLR1404, appears to have the lowest (0.063 ± 0.005 Gy/MBq). At administered activities of up to 74 MBq (3.7 GBq/kg), mice did not experience signs of toxicity. In addition, a single dose of CLR 125 reduced the volume of orthotopic primary TNBC xenografts by ∼60% compared to control vehicle (p
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CLR 125 Auger Electrons for the Targeted Radiotherapy of Triple-Negative Breast Cancer
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Autor/in / Beteiligte Person: | Grudzinski, Joseph ; Weichmann, Ashley M. ; Larrabee, Jason ; Bednarz, Bryan ; Titz, Benjamin ; Kozak, Kevin R. ; Moser, Amy R. ; Jeffery, Justin J. ; Lange, Kristofer ; Longino, Marc ; Marsh, Ian |
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Zeitschrift: | Cancer Biotherapy and Radiopharmaceuticals, Jg. 33 (2018-04-01), S. 87-95 |
Veröffentlichung: | Mary Ann Liebert Inc, 2018 |
Medientyp: | unknown |
ISSN: | 1557-8852 (print) ; 1084-9785 (print) |
DOI: | 10.1089/cbr.2017.2376 |
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