Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK
In: iScience, Jg. 24 (2021-09-01), S. 102963-102963
Online
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Zugriff:
Summary Long-chain triglycerides (LCTs) intake strongly stimulates GIP secretion from enteroendocrine K cells and induces obesity and insulin resistance partly due to GIP hypersecretion. In this study, we found that medium-chain triglycerides (MCTs) inhibit GIP secretion after single LCT ingestion and clarified the mechanism underlying MCT-induced inhibition of GIP secretion. MCTs reduced the CCK effect after single LCT ingestion in wild-type (WT) mice, and a CCK agonist completely reversed MCT-induced inhibition of GIP secretion. In vitro studies showed that medium-chain fatty acids (MCFAs) inhibit long-chain fatty acid (LCFA)-stimulated CCK secretion and increase in intracellular Ca2+ concentrations through inhibition of GPR120 signaling. Long-term administration of MCTs reduced obesity and insulin resistance in high-LCT diet-fed WT mice, but not in high-LCT diet-fed GIP-knockout mice. Thus, MCT-induced inhibition of GIP hypersecretion reduces obesity and insulin resistance under high-LCT diet feeding condition.
Graphical abstract
Highlights • MCTs inhibit LCT-induced GIP secretion by reducing LCT-induced CCK action • MCFAs derived from MCTs are expected to have antagonistic properties to GPR120 • Inhibition of GIP secretion alleviates obesity under high-LCT diet feeding condition
Biological sciences; Physiology; Endocrinology
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Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK
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Autor/in / Beteiligte Person: | Inagaki, Nobuya ; Kanemaru, Yoshinori ; Kishino, Shigenobu ; Kato, Tomoko ; Hatoko, Tomonobu ; Sankoda, Akiko ; Kiyobayashi, Sakura ; Murata, Yuki ; Ogawa, Jun ; Yamane, Shunsuke ; Iwasaki, Kanako ; Harada, Norio ; Ikeguchi-Ogura, Eri ; Hirasawa, Akira |
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Zeitschrift: | iScience, Jg. 24 (2021-09-01), S. 102963-102963 |
Veröffentlichung: | Elsevier BV, 2021 |
Medientyp: | unknown |
ISSN: | 2589-0042 (print) |
DOI: | 10.1016/j.isci.2021.102963 |
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