Functional profile of cytomegalovirus (CMV)-specific CD8+ T cells and kinetics of NKG2C+ NK Cells associated with the resolution of CMV DNAemia in allogeneic stem cell transplant recipients
In: Journal of Medical Virology, Jg. 84 (2011-12-14), S. 259-267
Online
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Zugriff:
Immune mechanisms involved in control of cytomegalovirus (CMV) infection in the allogeneic stem cell transplantation setting have not been fully disclosed. CMV pp65 and IE-1-specific CD8(+) T cells expressing IFN-γ, TNF-α, and CD107a, alone or in combination, and NKG2C(+) NK cells were prospectively enumerated during 13 episodes of CMV DNAemia. The expansion of monofunctional and polyfunctional CD8(+) T cells was associated with CMV DNAemia clearance. The size and functional diversity of the expanding CD8(+) T-cell population was greater in self-resolved episodes than in episodes treated with antivirals. These differences were related to the magnitude of expansion of cognate antigen IFN-γ CD4(+) T cells. The resolution of CMV DNAemia was associated frequently with a marked expansion of both CD56(dim) /CD16(+) NK cells and NKG2C(+) CD56(bright) /CD16(-) NK cells. The data lend support to the role of polyfunctional CD8(+) T cells in controlling CMV replication in the allogeneic stem cell transplantation setting, and suggest that NKG2C(+) NK cells may be involved critically in the resolution of CMV DNAemia episodes.
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Functional profile of cytomegalovirus (CMV)-specific CD8+ T cells and kinetics of NKG2C+ NK Cells associated with the resolution of CMV DNAemia in allogeneic stem cell transplant recipients
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Autor/in / Beteiligte Person: | Rafael de la Cámara ; Amat, Paula ; María Ángeles Clari ; García-Noblejas, Ana ; Costa, Elisa ; Benet, Isabel ; Solano, Carlos ; Javier María García López ; Navarro, David ; Bravo, Dayana ; Muñoz-Cobo, Beatriz ; María José Remigia ; Jose B Nieto |
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Zeitschrift: | Journal of Medical Virology, Jg. 84 (2011-12-14), S. 259-267 |
Veröffentlichung: | Wiley, 2011 |
Medientyp: | unknown |
ISSN: | 0146-6615 (print) |
DOI: | 10.1002/jmv.22254 |
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