Haploidentical transplantation outcomes for secondary acute myeloid leukemia: Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT) study
In: American Journal of Hematology American Journal of Hematology, Wiley, 2018, 93 (6), pp.769-777. ⟨10.1002/ajh.25087⟩ American Journal of Hematology, 2018, 93 (6), pp.769-777. ⟨10.1002/ajh.25087⟩; (2018)
Online
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Zugriff:
International audience; Secondary acute myeloid leukemia (sAML) traditionally has inferior outcomes compared to de novo AML. Allogeneic hematopoietic cell transplantation (HCT) is the sole potentially curative therapy. This study analyzes the outcomes for unmanipulated haploidentical HCT (haploHCT) for sAML using the Acute Leukemia Working Party (ALWP) registry of the European Society for Blood and Marrow Transplantation (EBMT). We identified 154 patients with sAML who underwent haploHCT from 2006 to 2016. Median age at HCT was 60 years with time from diagnosis to HCT 5 months. At transplantation, 69 patients were in first CR and 85 had active disease. Fifty-seven (38.0%) patients underwent myeloablative conditioning and 97 (62.0%) reduced intensity conditioning (RIC) conditioning. Multivariate analysis showed that there was no difference in RI, nonrelapse mortality (NRM), leukemia free survival (LFS), overall survival (OS), or GVHD-free/relapse free survival (GRFS) for conditioning intensity, age, performance status, or graft source. Active disease was associated with higher RI and inferior LFS, OS, and GRFS compared with patients in CR at time of transplant. T-cell depletion with anti-thymoglobulin resulted in higher NRM and inferior LFS, OS, and GRFS compared to post-transplant cyclophosphamide (PTCy) (HR 2.25, 2.01, 2.16, and 1.73, respectively with P values
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Haploidentical transplantation outcomes for secondary acute myeloid leukemia: Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT) study
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| Autor/in / Beteiligte Person: | Tischer, Johanna ; Santarone, Stella ; Ehninger, Gerhard ; Mailhol, Audrey ; Koc, Yener ; Castagna, Luca ; Labopin, Myriam ; Polge, Emmanuelle ; Ruggeri, Annalisa ; Forcade, Edouard ; Ciceri, Fabio ; Nagler, Arnon ; Mohty, Mohamad ; Li, Zhuoyan ; Savani, Bipin N. ; M. T. Van Lint ; Blaise, Didier ; Van Lint, M. T. ; Service d'hématologie clinique et de thérapie cellulaire [CHU Saint-Antoine] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU) ; Centre de Recherche Saint-Antoine (CR Saint-Antoine) ; Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) ; IRCCS Ospedale San Raffaele [Milan, Italy] ; Service d’Hématologie [Institut Paoli Calmettes, Marseille] ; Paoli-Calmettes, Institut ; Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC) ; Centre de Recherche en Cancérologie de Marseille (CRCM) ; Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes ; Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU) ; Department of Internal Medicine III [Munich, Germany] ; Hematopoietic Stem Cell Transplantation [Munich, Germany] ; Ludwig Maximilian University [Munich] (LMU)-Ludwig Maximilian University [Munich] (LMU) ; Technische Universität Dresden = Dresden University of Technology (TU Dresden) ; Stem Cell Transplant Unit [Antalya, Turkey] ; Medical Park Antalya Hospital [Turkey] ; Department of Hematology [Pescara, Italy] ; Bone Marrow Transplant Center [Pescara, Italy]-Ospedale Civile - BMT Center [Pescara, Italy] ; Composantes innées de la réponse immunitaire et différenciation (CIRID) ; Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS) ; Département d'Hématologie [Marseille] ; Unité de Transplantation et de Thérapie Cellulaire [Marseille] ; Transplant Unit [Milano, Italy] (Department of Hemato-oncology) ; Humanitas Cancer Center [Milano, Italy] ; European Society for Blood and Marrow Transplantation (EBMT) ; Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (UPMC) ; Université Pierre et Marie Curie - Paris 6 (UPMC) ; CHU Saint-Antoine [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) ; Centre de Recherche Saint-Antoine (CRSA) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) ; Aix Marseille Université (AMU)-Institut Paoli-Calmettes ; Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
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| Quelle: | American Journal of Hematology American Journal of Hematology, Wiley, 2018, 93 (6), pp.769-777. ⟨10.1002/ajh.25087⟩ American Journal of Hematology, 2018, 93 (6), pp.769-777. ⟨10.1002/ajh.25087⟩; (2018) |
| Veröffentlichung: | Wiley-Liss Inc., 2018 |
| Medientyp: | unknown |
| ISSN: | 0361-8609 (print) ; 1096-8652 (print) |
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