Benchtop and Animal Validation of a Projective Imaging System for Potential Use in Intraoperative Surgical Guidance
In: PLoS ONE, Jg. 11 (2016-07-01), Heft 7
Online
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Zugriff:
We propose a projective navigation system for fluorescence imaging and image display in a natural mode of visual perception. The system consists of an excitation light source, a monochromatic charge coupled device (CCD) camera, a host computer, a projector, a proximity sensor and a Complementary metal-oxide-semiconductor (CMOS) camera. With perspective transformation and calibration, our surgical navigation system is able to achieve an overall imaging speed higher than 60 frames per second, with a latency of 330 ms, a spatial sensitivity better than 0.5 mm in both vertical and horizontal directions, and a projection bias less than 1 mm. The technical feasibility of image-guided surgery is demonstrated in both agar-agar gel phantoms and an ex vivo chicken breast model embedding Indocyanine Green (ICG). The biological utility of the system is demonstrated in vivo in a classic model of ICG hepatic metabolism. Our benchtop, ex vivo and in vivo experiments demonstrate the clinical potential for intraoperative delineation of disease margin and image-guided resection surgery.
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Benchtop and Animal Validation of a Projective Imaging System for Potential Use in Intraoperative Surgical Guidance
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Autor/in / Beteiligte Person: | Gan, Qi ; Hu, Chuanzhen ; Wang, Dong ; Wang, Xinrui ; Xu, Ronald X. ; Ye, Jian ; Shao, Pengfei ; Zhang, Zeshu |
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Zeitschrift: | PLoS ONE, Jg. 11 (2016-07-01), Heft 7 |
Veröffentlichung: | Public Library of Science, 2016 |
Medientyp: | unknown |
ISSN: | 1932-6203 (print) |
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