A Comprehensive Review of Rapid-Onset Opioids for Breakthrough Pain
In: CNS Drugs, Jg. 26 (2012-06-01), S. 509-535
Online
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Zugriff:
Breakthrough pain (BTP) is a transitory pain (reaching maximum severity in ~15 minutes and lasting ~60 minutes in patients with cancer) that occurs despite the management of chronic pain with long-term around-the-clock analgesia. BTP occurs in 33-65% of patients with chronic cancer pain and in ~70% of patients with chronic noncancer pain. BTP has historically been managed with short-acting opioids; however, these medications have a pharmacokinetic profile that does not correlate with the sudden onset and short time to maximum severity of BTP. Interest in rapid-onset opioids to relieve BTP has therefore been growing. This comprehensive review aims to summarize the currently available clinical data for the approved rapid-onset opioids, which comprise different formulations of fentanyl, a μ-opioid receptor agonist with anaesthetic and analgesic properties. Administration routes for fentanyl in the management of BTP currently include the transmucosal and intranasal routes; an intrapulmonary formulation is also in development. The findings of this review suggest that the efficacy and safety of the approved rapid-onset opioids are comparable.
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A Comprehensive Review of Rapid-Onset Opioids for Breakthrough Pain
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Autor/in / Beteiligte Person: | Smith, Howard S. |
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Zeitschrift: | CNS Drugs, Jg. 26 (2012-06-01), S. 509-535 |
Veröffentlichung: | Springer Science and Business Media LLC, 2012 |
Medientyp: | unknown |
ISSN: | 1172-7047 (print) |
DOI: | 10.2165/11630580-000000000-00000 |
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