Corticotroph tumor progression after bilateral adrenalectomy (Nelson’s syndrome): systematic review and expert consensus recommendations
In: European Journal of Endocrinology European Journal of Endocrinology, 2021, 184 (3), pp.P1-P16. ⟨10.1530/EJE-20-1088⟩ European Journal of Endocrinology, 184(3), P1-P16. Bioscientifica Ltd Eur J Endocrinol EUROPEAN JOURNAL OF ENDOCRINOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname; (2021-01-12)
Online
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Zugriff:
Background Corticotroph tumor progression (CTP) leading to Nelson’s syndrome (NS) is a severe and difficult-to-treat complication subsequent to bilateral adrenalectomy (BADX) for Cushing’s disease. Its characteristics are not well described, and consensus recommendations for diagnosis and treatment are missing. Methods A systematic literature search was performed focusing on clinical studies and case series (≥5 patients). Definition, cumulative incidence, treatment and long-term outcomes of CTP/NS after BADX were analyzed using descriptive statistics. The results were presented and discussed at an interdisciplinary consensus workshop attended by international pituitary experts in Munich on October 28, 2018. Results Data covered definition and cumulative incidence (34 studies, 1275 patients), surgical outcome (12 studies, 187 patients), outcome of radiation therapy (21 studies, 273 patients), and medical therapy (15 studies, 72 patients). Conclusions We endorse the definition of CTP-BADX/NS as radiological progression or new detection of a pituitary tumor on thin-section MRI. We recommend surveillance by MRI after 3 months and every 12 months for the first 3 years after BADX. Subsequently, we suggest clinical evaluation every 12 months and MRI at increasing intervals every 2–4 years (depending on ACTH and clinical parameters). We recommend pituitary surgery as first-line therapy in patients with CTP-BADX/NS. Surgery should be performed before extrasellar expansion of the tumor to obtain complete and long-term remission. Conventional radiotherapy or stereotactic radiosurgery should be utilized as second-line treatment for remnant tumor tissue showing extrasellar extension
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Corticotroph tumor progression after bilateral adrenalectomy (Nelson’s syndrome): systematic review and expert consensus recommendations
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Autor/in / Beteiligte Person: | Perez-Rivas, Luis G. ; Elenkova, Atanaska ; Reincke, Martin ; Theodoropoulou, Marily ; Rubinstein, German ; Elisabeth F.C. van Rossum ; Chabre, Olivier ; Grossman, Ashley B. ; Detomas, Mario ; Karavitaki, Niki ; Ritzel, Katrin ; Lacroix, André ; Bancos, Irina ; Valassi, Elena ; Brue, Thierry ; Losa, Marco ; Laws, Edward R. ; Schopohl, Jochen ; Murakami, Masanori ; Daniele, Andrea ; Honegger, Juergen ; Albani, Adriana ; Zacharieva, Sabina ; Buchfelder, Michael ; Stratakis, Constantine A. ; Pivonello, Rosario ; Assié, Guillaume ; Heaney, Anthony P. ; Francesca Pecori Giraldi ; Gomez-Sanchez, Celso E. ; Ceccato, Filippo ; Rainey, William E. ; Newell-Price, John ; Guido Di Dalmazi ; Findling, James W. ; Sbiera, Silviu ; Ludwig-Maximilians-Universität München (LMU) ; Institut Cochin (IC UM3 (UMR 8104 / U1016)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité) ; Hôpital Cochin [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Mayo Clinic [Rochester] ; Marseille medical genetics - Centre de génétique médicale de Marseille (MMG) ; Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Institut Marseille Maladies Rares (MarMaRa) ; Aix Marseille Université (AMU) ; Service d'endocrinologie, diabète, maladies métaboliques [Hôpital de la Conception - APHM] ; Universitätsklinikum Erlangen [Erlangen] ; Centre Hospitalier Universitaire [Grenoble] (CHU) ; Università degli Studi di Padova = University of Padua (Unipd) ; University of Würzburg = Universität Würzburg ; University of Bologna/Università di Bologna ; Medical University of Sofia [Bulgarie] ; Medical College of Wisconsin [Milwaukee] (MCW) ; Queen Mary University of London (QMUL) ; University of Mississippi Medical Center (UMMC) ; School of Medicine [Los Angeles] ; University of California [Los Angeles] (UCLA) ; University of California (UC)-University of California (UC) ; University of Tübingen ; University of Birmingham [Birmingham] ; Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) ; University of Oxford ; University Hospitals Birmingham [Birmingham, Royaume-Uni] ; Centre Hospitalier de l'Université de Montréal (CHUM) ; Université de Montréal (UdeM) ; Harvard Medical School [Boston] (HMS) ; IRCCS San Raffaele Scientific Institute [Milan, Italie] ; Tokyo Medical and Dental University [Japan] (TMDU) ; University of Sheffield [Sheffield] ; Università degli Studi di Milano = University of Milan (UNIMI) ; University of Naples Federico II = Università degli studi di Napoli Federico, II ; University of Michigan [Ann Arbor] ; University of Michigan System ; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) ; Erasmus University Medical Center [Rotterdam] (Erasmus MC) ; Hospital de la Santa Creu i Sant Pau ; Gall, Valérie ; Medicine, Internal ; Reincke, M. ; Albani, A. ; Assie, G. ; Bancos, I. ; Brue, T. ; Buchfelder, M. ; Chabre, O. ; Ceccato, F. ; Daniele, A. ; Detomas, M. ; Dalmazi, G. D. ; Elenkova, A. ; Findling, J. ; Grossman, A. B. ; Gomez-Sanchez, C. E. ; Heaney, A. P. ; Honegger, J. ; Karavitaki, N. ; Lacroix, A. ; Laws, E. R. ; Losa, M. ; Murakami, M. ; Newell-Price, J. ; Giraldi, F. P. ; Perez-Rivas, L. G. ; Pivonello, R. ; Rainey, W. E. ; Sbiera, S. ; Schopohl, J. ; Stratakis, C. A. ; Theodoropoulou, M. ; van Rossum, E. F. C. ; Valassi, E. ; Zacharieva, S. ; Rubinstein, G. ; Ritzel, K. ; Di Dalmazi G. ; A.B., Grossman ; C.E., Gomez-Sanchez ; A.P., Heaney ; E.R., Laws ; F.P., Giraldi ; L.G., Perez-Rivas ; W.E., Rainey ; C.A., Stratakis ; van Rossum E.F.C. |
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Quelle: | European Journal of Endocrinology European Journal of Endocrinology, 2021, 184 (3), pp.P1-P16. ⟨10.1530/EJE-20-1088⟩ European Journal of Endocrinology, 184(3), P1-P16. Bioscientifica Ltd Eur J Endocrinol EUROPEAN JOURNAL OF ENDOCRINOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname; (2021-01-12) |
Veröffentlichung: | HAL CCSD, 2021 |
Medientyp: | unknown |
ISSN: | 0804-4643 (print) ; 1479-683X (print) |
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