An exploratory study of neopterin and kynurenine pathway in pterygium
In: Pteridines, Jg. 30 (2019), Heft 1, S. 153-157
Online
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Zugriff:
Pterygium is an inflammatory, vascular and degenerative disorder with unknown aetiology. The aim of this study was to evaluate the changes in neopterin levels, reflecting T-cell immunity, and the kynurenine pathway, the main degradation process of tryptophan, in pterygium. For this purpose, neopterin concentrations were measured in serum and tear samples by enzyme-linked immunosorbent assay (ELISA) in pterygium patients (n=31) and control group (n=32). Kynurenine (KYN) and tryptophan (TRP) serum levels were simultaneously determined by high-performance liquid chromatography (HPLC) for evaluation of the kynurenine pathway. Serum neopterin concentrations and kynurenine to tryptophan ratio (KYN/TRP) as an index of tryptophan breakdown were found increased in pterygium compared to controls (p
Titel: |
An exploratory study of neopterin and kynurenine pathway in pterygium
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Autor/in / Beteiligte Person: | Kilicarslan, Bilge ; Baydar, Terken ; Ozlem Evren Kemer ; Girgin, Gözde ; Cardak, Aziz |
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Zeitschrift: | Pteridines, Jg. 30 (2019), Heft 1, S. 153-157 |
Veröffentlichung: | De Gruyter, 2019 |
Medientyp: | unknown |
ISSN: | 2195-4720 (print) ; 0933-4807 (print) |
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