Glucose and Counterregulatory Responses to Exercise in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia Using Closed-Loop Insulin Delivery: A Randomized Crossover Study
In: Diabetes Care, Jg. 43 (2019-12-03), S. 480-483
Online
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Zugriff:
OBJECTIVE To evaluate exercise-related glucose and counterregulatory responses (CRR) in adults with type 1 diabetes with impaired awareness of hypoglycemia (IAH) using hybrid closed-loop (HCL) insulin delivery to maintain glucose homeostasis. RESEARCH DESIGN AND METHODS Twelve participants undertook 45-min high-intensity intermittent exercise (HIIE) and moderate-intensity exercise (MIE) in random order. The primary outcome was continuous glucose monitoring (CGM) time in range (70–180 mg/dL) for 24-h post–exercise commencement. RESULTS CGM time in range was similar for HIIE and MIE (median 79.5% [interquartile range 73.2, 87.6] vs. 76.1% [70.3, 83.9], P = 0.37), and time with levels CONCLUSIONS IAH adults using HCL undertaking HIIE and MIE exhibit heterogeneity in CRR. Novel findings were a preserved cortisol response and variable catecholamine responses to HIIE.
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Glucose and Counterregulatory Responses to Exercise in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia Using Closed-Loop Insulin Delivery: A Randomized Crossover Study
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Autor/in / Beteiligte Person: | Jayawardene, Dilshani ; Gooley, Judith L. ; Jones, Hannah ; Richard J MacIsaac ; David N O'Neal ; Obeyesekere, Varuni R. ; Sybil A McAuley ; Paldus, Barbora ; Melissa H Lee ; Jenkins, Alicia J. ; Sundararajan, Vijaya ; Vogrin, Sara ; Ward, Glenn M. ; Andre La Gerche |
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Zeitschrift: | Diabetes Care, Jg. 43 (2019-12-03), S. 480-483 |
Veröffentlichung: | American Diabetes Association, 2019 |
Medientyp: | unknown |
ISSN: | 1935-5548 (print) ; 0149-5992 (print) |
DOI: | 10.2337/dc19-1433 |
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