Molecular Cloning of a Novel Human cDNA Homologous to CDC10 in Saccharomyces cerevisiae
In: Biochemical and Biophysical Research Communications, Jg. 202 (1994-07-01), S. 82-87
Online
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Zugriff:
We isolated a novel human cDNA, termed hCDC10, whose predicted product showed a high degree of homology to the CDC10 protein of Saccharomyces cerevisiae. This cDNA contained an open reading frame of 1254 nucleotides encoding 418 amino acids, which included a GTP-binding motif, GX4GKS--DX2G--KXD. The predicted peptide sequence also revealed partial amino-acid identity (40-50%) with Diff 6 in Drosophila and with H5 in mouse, Each of these sequence homologues, including Saccharomyces cerevisiae CDC10, contains the GTP-binding motif. Northern blot analyses indicated that the hCDC10 gene is expressed ubiquitously in normal tissues.
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Molecular Cloning of a Novel Human cDNA Homologous to CDC10 in Saccharomyces cerevisiae
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Autor/in / Beteiligte Person: | Nakatsuru, Shuichi ; Nakamura, Yusuke ; Sudo, Kazunori |
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Zeitschrift: | Biochemical and Biophysical Research Communications, Jg. 202 (1994-07-01), S. 82-87 |
Veröffentlichung: | Elsevier BV, 1994 |
Medientyp: | unknown |
ISSN: | 0006-291X (print) |
DOI: | 10.1006/bbrc.1994.1896 |
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