A novel chemokine, Leukotactin-1, induces chemotaxis, pro-atherogenic cytokines, and tissue factor expression in atherosclerosis
In: Atherosclerosis, Jg. 161 (2002-04-01), S. 255-260
Online
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Zugriff:
Chemokines such as monocyte chemoattractant protein (MCP) -1 and interleukin (IL)-8 are known to be involved in various processes in atherosclerosis such as plaque formation, plaque rupture, and thrombus formation. We investigated whether a new chemokine, Leukotactin (LKN)-1, is involved in atherosclerosis. We tested the expression of LKN-1 by immunohistochemical methods in carotid atherosclerotic plaque specimen. Induction of pro-inflammatory cytokines, transmigration, and tissue factor (TF) expression were tested in THP-1 cells and human peripheral blood monocytes treated with recombinant human LKN-1. Immunohistochemical analyses revealed that expression of LKN-1 occurs in regions of plaques rich in foam cells. In a Boyden chamber assay, THP-1 cells treated with 0.01–10 nM of LKN-1 transmigrated through gelatin coated filters in a dose dependent manner. LKN-1 also induced the transient expression of TNF-α, IL-8, and MCP-1 within 15 min of the treatment of the THP-1 cells. When peripheral blood monocytes were treated with LKN-1, expression levels of TF and TF-mediated procoagulating activity were induced in a time- and dose-dependent manner. These results raise the possibility that LKN-1 is another chemokine that is involved in the atherogenesis. LKN-1 may chemoattract immune cells into the plaque, induce pro-inflammatory cytokines, and produce thrombi by inducing TF expression.
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A novel chemokine, Leukotactin-1, induces chemotaxis, pro-atherogenic cytokines, and tissue factor expression in atherosclerosis
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Autor/in / Beteiligte Person: | Byung Boong Lee ; Park, Jeong-Euy ; Choi, Yoon-Ho ; Kim, Dong-Ik ; Kim, Se-Hwa ; Euy Myoung Jeong ; Lee, Won-Ha ; Young Sun Cho ; Kwon, Byoung S. |
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Zeitschrift: | Atherosclerosis, Jg. 161 (2002-04-01), S. 255-260 |
Veröffentlichung: | Elsevier BV, 2002 |
Medientyp: | unknown |
ISSN: | 0021-9150 (print) |
DOI: | 10.1016/s0021-9150(01)00634-7 |
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