Small Split Doses of CD34+ Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy
In: Case Reports in Oncological Medicine, Jg. 2017 (2017)
Online
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Zugriff:
Cumulative myelosuppression is the main limiting factor for administration of repeated cycles of chemotherapy. We present a case series of five pediatric patients with high-risk solid malignancies who received small split peripheral blood stem cells (PBSC) doses of less than 1 × 106/kg CD34+cells obtained after a single leukapheresis procedure and given after repeated cycles of ICE (ifosfamide, carboplatin, and etoposide) chemotherapy. Mean duration to absolute neutrophil count (ANC) recovery to >1000/mm3and platelet recovery to >50 × 103/mm3was 17.1 and 24.3 days. Using split doses of PBSC prevented prolonged neutropenia after repeated cycles of submyeloablative chemotherapy.
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Small Split Doses of CD34+ Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy
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Autor/in / Beteiligte Person: | Yankelevich, Maxim ; Mentkevich, George ; Dolgopolov, Igor ; Savaşan, Süreyya ; Chu, Roland |
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Zeitschrift: | Case Reports in Oncological Medicine, Jg. 2017 (2017) |
Veröffentlichung: | Hindawi Limited, 2017 |
Medientyp: | unknown |
ISSN: | 2090-6714 (print) ; 2090-6706 (print) |
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