A phase II study of rituximab combined with pirarubicin–cyclophosphamide, vincristine and prednisolone regimen as first-line therapy for patients with indolent B-cell lymphoma
In: Leukemia & Lymphoma, Jg. 53 (2011-08-10), S. 247-253
Online
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Zugriff:
The anthracycline drug pirarubicin (tetrahydropyranyl-adriamycin [THP]) apparently has been reported to show fewer cardiotoxic effects than doxorubicin. We have previously described the effectiveness of the R-THP-COP regimen comprising rituximab, cyclophosphamide, pirarubicin, vincristine and prednisolone in patients with diffuse large B-cell lymphoma. We conducted a phase II study to determine the effectiveness of a regimen incorporating rituximab (R-THP-COP) for patients with previously untreated advanced-stage indolent CD20-positive B-cell lymphoma according to the Working Formulation and World Health Organization classification. Four to six courses of the regimen were administered every 3 weeks in 50 patients. The complete remission rate was 57%, while the 3-year overall survival rate was 92%. Regimen-related death was not observed. The R-THP-COP regimen appears very effective for patients with previously untreated advanced-stage indolent CD20-positive B-cell lymphoma. The present results indicate the need for randomized trials of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) and R-THP-COP among patients with CD20-positive indolent lymphoma.
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A phase II study of rituximab combined with pirarubicin–cyclophosphamide, vincristine and prednisolone regimen as first-line therapy for patients with indolent B-cell lymphoma
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Autor/in / Beteiligte Person: | Hara, Takeshi ; Moriwaki, Hisataka ; Goto, Naoe ; Kasahara, Senji ; Yamada, Toshiki ; Kanemura, Nobuhiro ; Goto, Hideko ; Sawada, Michio ; Fukuno, Kenji ; Takahashi, Takeshi ; Takami, Tsuyoshi ; Tsurumi, Hisashi ; Yoshikawa, Takeshi ; Shimizu, Masahito ; Kitagawa, Junichi |
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Zeitschrift: | Leukemia & Lymphoma, Jg. 53 (2011-08-10), S. 247-253 |
Veröffentlichung: | Informa UK Limited, 2011 |
Medientyp: | unknown |
ISSN: | 1029-2403 (print) ; 1042-8194 (print) |
DOI: | 10.3109/10428194.2011.606383 |
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