Association of NRH:Quinone Oxidoreductase 2 Gene Promoter Polymorphism With Higher Gene Expression and Increased Susceptibility to Parkinson's Disease
In: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Jg. 63 (2008-02-01), S. 127-134
Online
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Zugriff:
The N-ribosyldihydronicotinamide (NRH):quinone oxidoreductase 2 (NQO2) gene encodes an enzyme that catalyzes activation of quinones. Blood DNA from 80 control individuals and 118 age-matched Parkinson's disease patients were analyzed for NQO2 gene promoter polymorphisms. The results revealed three allelic variants, designated I-29, I-16, and D. These results were confirmed in fibroblast cell lines. In patients with Parkinson's disease, there was a significant increase in the frequency of the D allele, but there was no difference in the frequency of the alleles in familial compared to sporadic Parkinson's disease. The D and I-16 promoters direct higher NQO2 gene expression that results in higher enzyme activity. Overexpression of NQO2 in the catecholaminergic neuroblastoma SH-SY5Y cells resulted in increased production of reactive oxygen species when exposed to exogenous dopamine. The results suggest that the association of the D promoter with Parkinson's disease may be due to an increase in expression of the NQO2 gene.
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Association of NRH:Quinone Oxidoreductase 2 Gene Promoter Polymorphism With Higher Gene Expression and Increased Susceptibility to Parkinson's Disease
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Autor/in / Beteiligte Person: | Le, Weidong ; Stringer, Janet L. ; Pan, Tianhong ; Jaiswal, Anil K. ; Wang, Wei |
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Zeitschrift: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Jg. 63 (2008-02-01), S. 127-134 |
Veröffentlichung: | Oxford University Press (OUP), 2008 |
Medientyp: | unknown |
ISSN: | 1758-535X (print) ; 1079-5006 (print) |
DOI: | 10.1093/gerona/63.2.127 |
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