Mitigation of pyrexia by a Th-1-biased IgG subclass response after infection with equine herpesvirus type 1 in horses pre-immunized with inactivated vaccine
In: The Journal of veterinary medical science, Jg. 74 (2012-01-11), Heft 6
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Zugriff:
The immunoglobulin G (IgG) subclass response was investigated in horses with or without pyrexia after natural infection with equine herpesvirus type 1 (EHV-1) in the field. All horses were kept at the training centers of the Japan Racing Association and were immunized with an inactivated EHV-1 vaccine before EHV-1 infection. An IgG subclass response dominated by IgGa and IgGb was induced in horses without pyrexia after EHV-1 infection. In contrast, horses that developed pyrexia showed increased IgGc and IgG (T) subclass production in addition to IgGa and IgGb. Although inactivated EHV-1 vaccines are considered to induce a mainly Th-2-biased response, these results indicated that the responses in horses inoculated with inactivated EHV-1 vaccine were not uniform, and that horses with a Th-1-biased response were likely to be protected from pyrexia.
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Mitigation of pyrexia by a Th-1-biased IgG subclass response after infection with equine herpesvirus type 1 in horses pre-immunized with inactivated vaccine
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Autor/in / Beteiligte Person: | Kato, Tomohiro ; Bannai, Hiroshi ; Yamanaka, Takashi ; Matsumura, Tomio ; Nemoto, Manabu ; Tsujimura, Koji ; Sugiura, Takeo ; Kondo, Takashi ; Maeda, Ken |
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Zeitschrift: | The Journal of veterinary medical science, Jg. 74 (2012-01-11), Heft 6 |
Veröffentlichung: | 2012 |
Medientyp: | unknown |
ISSN: | 1347-7439 (print) |
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