Predictive role of HER2/neu, topoisomerase-II-alpha, and tissue inhibitor of metalloproteinases (TIMP-1) for response to adjuvant taxane-based chemotherapy in patients with intermediate-risk breast cancer: results from the WSG-AGO EC-Doc trial
In: Breast Cancer Research and Treatment, Jg. 150 (2015-02-28), S. 279-288
Online
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Zugriff:
Taxane–anthracycline-based adjuvant chemotherapy is standard of care in patients with node-positive breast cancer (BC) but is also associated with severe side effects and significant costs. It is yet unclear, which biomarkers would predict benefit from taxanes and/or general chemoresistance. In this study, we investigate a large cohort of patients with intermediate-risk BC treated within the WSG EC-DOC Trial for the predictive impact of topoisomerase-II-alpha, HER2/neu, and TIMP-1. Tumor tissue was available in a representative cohort of 772 cases of the WSG EC-DOC Trial collective which compared 4xEC-4xDoc versus 6xCEF/CMF. In addition to hormone receptor status and Ki-67, HER2/neu+ and topoisomerase-II-alpha status using fluorescence in situ hybridisation (FISH) and immunohistochemistry, TIMP-1 using immunohistochemistry, and aneuploidy of chromosome 17 using FISH were evaluated and correlated with outcome and taxane benefit. There was significant superiority of EC-Doc over CEF regarding 5-year DFS (90 vs. 80 %, respectively, p = 0.006) particularly in patient subgroups defined by HR+, HER2/neu+, high proliferation (i.e., Ki-67 ≥ 20 %), patient age >50 years old and normal chromosome 17 status, high TIMP-1 and low topoisomerase-II-alpha protein expression. Significant prognostic factors in multivariate analysis were EC-Doc therapy (HR = 0.61; 95 %CI 0.38–0.986), age
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Predictive role of HER2/neu, topoisomerase-II-alpha, and tissue inhibitor of metalloproteinases (TIMP-1) for response to adjuvant taxane-based chemotherapy in patients with intermediate-risk breast cancer: results from the WSG-AGO EC-Doc trial
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Autor/in / Beteiligte Person: | Jänicke, Fritz ; Kreipe, Hans ; Kuhn, Walther ; Augustin, Doris ; Kates, Ronald E. ; Huober, Jens ; Hartmann, Arndt ; Möbus, Volker ; Brünner, Nils ; Bartels, Annette ; Nitz, Ulrike ; Mohrmann, Svjetlana ; Gluz, Oleg ; Pelz, E ; Harbeck, Nadia ; Thomssen, Christoph ; Erber, Ramona ; Moustafa, Zehra ; Kiechle, Marion ; Liedtke, Cornelia |
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Zeitschrift: | Breast Cancer Research and Treatment, Jg. 150 (2015-02-28), S. 279-288 |
Veröffentlichung: | Springer Science and Business Media LLC, 2015 |
Medientyp: | unknown |
ISSN: | 1573-7217 (print) ; 0167-6806 (print) |
DOI: | 10.1007/s10549-015-3310-x |
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