Cytomegalovirus reactivation after hematopoietic stem cell transplant with CMV‐IG prophylaxis: A monocentric retrospective analysis
In: Journal of Medical Virology, Jg. 93 (2021-02-19), S. 6292-6300
Online
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Zugriff:
Human cytomegalovirus (CMV) represents the most common viral infection after hematopoietic stem cell transplant (HSCT), mainly occurring as reactivation from latency in seropositive patients, with a different prevalence based on the extent and timing of seroconversion in a specific population. Here, we retrospectively analyzed a cohort of patients who underwent HSCT at our Institution between 2013 and 2018, all of whom were prophylactically treated with CMV-IG (Megalotect Biotest®), to define the incidence and clinical outcomes of CMV reactivation and clinically significant infection. CMV infection occurred in 69% of our patient series, mainly resulting from reactivation, and CMV clinically significant infection (CS-CMVi) occurred in 48% of prophylactically treated patients. CMV infection and CS-CMVi impacted neither on relapse incidence nor on overall survival nor on relapse-free survival. Moreover, a very low incidence of CMV end-organ disease was documented. CMV-IG used alone as prophylactic therapy after HSCT does not effectively prevent CMV reactivation.
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Cytomegalovirus reactivation after hematopoietic stem cell transplant with CMV‐IG prophylaxis: A monocentric retrospective analysis
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Autor/in / Beteiligte Person: | Bresciani, Paola ; Pecorari, Monica ; Messerotti, Andrea ; Comoli, Patrizia ; Banchelli, Federico ; Colasante, Corrado ; Galassi, Laura ; Forghieri, Fabio ; Giubbolini, Rachele ; Cuoghi, Angela ; Bettelli, Francesca ; D'Amico, Roberto ; Potenza, Leonardo ; Trenti, Tommaso ; Gennari, William ; Marasca, Roberto ; Pioli, Valeria ; Luppi, Mario ; Donatelli, Francesca ; Gilioli, Andrea ; Giusti, Davide ; Narni, Franco |
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Zeitschrift: | Journal of Medical Virology, Jg. 93 (2021-02-19), S. 6292-6300 |
Veröffentlichung: | Wiley, 2021 |
Medientyp: | unknown |
ISSN: | 1096-9071 (print) ; 0146-6615 (print) |
DOI: | 10.1002/jmv.26861 |
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