Flyscan opportunities in medicine: the case of quantum rattle based on gold quantum dots
In: Journal of Synchrotron Radiation Journal of Synchrotron Radiation, International Union of Crystallography, 2017, 24 (5), pp.991-999. ⟨10.1107/S1600577517009572⟩ Journal of Synchrotron Radiation, 2017, 24 (5), pp.991-999. ⟨10.1107/S1600577517009572⟩; (2017-09-01)
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Zugriff:
International audience; The new rapid scan method, Flyscan mode, implemented on the DiffAbs beamline at Synchrotron SOLEIL, allows fast micro-X-ray fluorescence data acquisition. It paves the way for applications in the biomedical field where a large amount of data is needed to generate meaningful information for the clinician. This study presents a complete set of data acquired after injection of gold-cluster-enriched mesoporous silica nanospheres, used as potential theranostic vectors, into rats. While classical X-ray fluorescence investigations (using step-by-step acquisitions) are based on a limited number of samples (approximately one per day at the DiffAbs beamline), the Flyscan mode has enabled gathering information on the interaction of nanometer-scale vectors in different organs such as liver, spleen and kidney at the micrometer scale, for five rats, in only a single five-day synchrotron shift. Moreover, numerous X-ray absorption near-edge structure spectra, which are beam-time-consuming taking into account the low concentration of these theranostic vectors, were collected
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Flyscan opportunities in medicine: the case of quantum rattle based on gold quantum dots
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| Autor/in / Beteiligte Person: | Berthault, Julien ; Jouanneau, Chantal ; Thiaudière, Dominique ; Chanéac, Corinne ; Leclercq, Nicolas ; Greisch, Jean-François ; Esteve, Emmanuel ; Leyh, Bernard ; Bazin, Dominique ; Reguer, Solenn ; Ronco, Pierre ; Daudon, Michel ; Boissière, Cédric ; Mocuta, Cristian ; Lugo, Gustavo ; Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP) ; Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ; Synchrotron SOLEIL (SSOLEIL) ; Centre National de la Recherche Scientifique (CNRS) ; Matériaux Hybrides et Nanomatériaux (LCMCP-MHN) ; Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ; Department of Chemistry [Liège] ; Université de Liège ; Institute of Nanotechnology [Karlsruhe] (INT) ; Karlsruhe Institute of Technology (KIT) ; CHU Tenon [AP-HP] ; Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (LCMCP-SMiLES) ; Matériaux Hybrides et Procédés (LCMCP-MHP ) ; Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
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| Quelle: | Journal of Synchrotron Radiation Journal of Synchrotron Radiation, International Union of Crystallography, 2017, 24 (5), pp.991-999. ⟨10.1107/S1600577517009572⟩ Journal of Synchrotron Radiation, 2017, 24 (5), pp.991-999. ⟨10.1107/S1600577517009572⟩; (2017-09-01) |
| Veröffentlichung: | HAL CCSD, 2017 |
| Medientyp: | unknown |
| ISSN: | 0909-0495 (print) ; 1600-5775 (print) |
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