Comparison of fingerstick hemoglobin A1c levels assayed by DCA 2000 with the DCCT/EDIC central laboratory assay: results of a Diabetes Research in Children Network (DirecNet) Study
In: Pediatric Diabetes, Jg. 6 (2005-03-01), S. 13-16
Online
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Zugriff:
The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) high-performance liquid chromatography (HPLC) method for measuring hemoglobin A1c (HbA1c) serves as a reference standard against which other assays are compared. The DCA 2000 + Analyzer (Bayer Inc., Tarrytown, NY, USA), which uses an immunoassay, is a very popular device for measuring HbA1c levels in pediatric diabetes practices.To determine how HbA1c values measured with the DCA 2000 in a multisite, pediatric diabetes clinic setting compare with corresponding HbA1c values measured in the DCCT/EDIC laboratory.To examine this question, the Diabetes Research in Children Network (DirecNet) used the DCA 2000 in five clinical centers to measure baseline HbA1c levels in 200 youth with type 1 diabetes mellitus (T1DM) (aged 12.5 +/- 2.8 yr) who were participating in an outpatient clinical trial. At the same visit, an additional blood sample was obtained, refrigerated, and shipped to the DCCT/EDIC central laboratory for determination of HbA1c values.The central laboratory HbA1c value averaged 8.0 +/- 0.9% (mean +/- SD), with a median (25th and 75th quartiles) of 7.8% (7.3 and 8.5%, respectively). The DCA 2000 HbA1c values were strongly correlated (r = 0.94, p0.001), but significantly higher than DCCT/EDIC central laboratory values with a mean difference of +0.2% (95% confidence interval +0.14 to 0.23%, p0.001). There was some variation in the differences between DCA 2000 and central laboratory values at the five clinical centers (p0.001) with mean differences ranging between 0.0 and 0.3%, but differences between the two methods did not vary significantly by age or gender.Measurements of HbA1c by the DCA 2000 compare favorably with the DCCT/EDIC central laboratory method, albeit with slightly higher values.
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Comparison of fingerstick hemoglobin A1c levels assayed by DCA 2000 with the DCCT/EDIC central laboratory assay: results of a Diabetes Research in Children Network (DirecNet) Study
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Autor/in / Beteiligte Person: | Tsalikian, Eva ; Ruedy, Katrina J. ; Linder, Barbara ; Buckingham, Bruce A. ; Sikes, Kristin A. ; Doyle, Elizabeth A. ; Fisher, Jennifer H. ; Clinton, Paula ; Tallant, Barbara ; Fiallo-Scharer, Rosanna ; Beck, Roy W. ; Bucksa, Jean M. ; Steffes, Michael W. ; Grave, Gilman D. ; Wysocki, Tim ; Kollman, Craig ; Weinzimer, Stuart A. ; Xing, Dongyuan ; Coffey, Julie ; Winer, Karen K. ; Silvester, Cynthia R. ; Ryan, Christopher M. ; H. Peter Chase ; Cox, Christopher ; White, Perrin C. ; White, Neil H. ; Bird, Keisha ; Fox, Larry A. ; Mauras, Nelly ; Nowicki, Maren ; Carol A. Van Hale ; Becker, Dorothy M. ; Lofton, Kelly L. ; Tamborlane, William V. ; Wilson, Darrell M. ; Larson, Linda F. ; Tansey, Michael ; Block, Jennifer M. |
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Zeitschrift: | Pediatric Diabetes, Jg. 6 (2005-03-01), S. 13-16 |
Veröffentlichung: | Hindawi Limited, 2005 |
Medientyp: | unknown |
ISSN: | 1399-5448 (print) ; 1399-543X (print) |
DOI: | 10.1111/j.1399-543x.2005.00088.x |
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