Interleukin 6, a possible autocrine growth and differentiation factor for the human megakaryocytic cell line, CMK
In: British Journal of Haematology, Jg. 77 (1991), S. 32-36
Online
unknown
Zugriff:
CMK is a human cell line derived from a megakaryoblastic leukaemia. It has characteristics of the megakaryocytic lineage, such as the presence of platelet peroxidase, membrane glycoproteins (GP)Ib and GPIIb/IIIa, alpha-granules, and demarcation membranes. The cell line proliferates autonomously in serum-containing medium. Here we report that the cell line expresses the gene for IL-6 and releases small quantities of the cytokine into the medium. Addition of exogenous IL-6 to cultures seeded into medium was found to promote growth of the cells. Conversely, addition of a neutralizing anti-IL-6 antibody inhibited cell growth. These data support the notion that autocrine IL-6 is one of the factors accounting for autonomous growth of the cell line.
Titel: |
Interleukin 6, a possible autocrine growth and differentiation factor for the human megakaryocytic cell line, CMK
|
---|---|
Autor/in / Beteiligte Person: | Sato, Takeyuki ; Fuse, Akira ; Billiau, A ; J Van Damme ; Kakuda, Harumi ; Shima, Y |
Link: | |
Zeitschrift: | British Journal of Haematology, Jg. 77 (1991), S. 32-36 |
Veröffentlichung: | Wiley, 1991 |
Medientyp: | unknown |
ISSN: | 1365-2141 (print) ; 0007-1048 (print) |
DOI: | 10.1111/j.1365-2141.1991.tb07944.x |
Schlagwort: |
|
Sonstiges: |
|