Reduction of CFU-GM and Circulating Hematopoietic Progenitors in a Subgroup of Children With Chronic Neutropenia Associated With Severe Infections and Delayed Recovery
In: PLoS ONE, Jg. 14 (2019), Heft 3, p e0213782
Online
unknown
Zugriff:
Myelopoiesis was evaluated in 66 pediatric patients with chronic neutropenia who were positive for anti-neutrophil antibodies (median age at diagnosis: 11 months, median neutrophil count at diagnosis: 419/μl). Other causes of neutropenia were excluded. Bone marrow morphology, clonogenic tests and/or the peripheral blood CD 34+ cell count, and apoptotic rate were evaluated in 61 patients with neutropenia lasting > 12 months or severe infections. The peripheral blood CD 34+ cell count and apoptotic rate were evaluated in five patients with shorter neutropenia. The median follow-up time was 29 months (range 7-180 months). Forty-seven patients (71.2%) had a spontaneous recovery after 7-180 months (median 29 months). The group of patients younger than 24 months at diagnosis (n = 50) had a higher probability of recovery (40/50 vs. 7/16 χ2 p
Titel: |
Reduction of CFU-GM and Circulating Hematopoietic Progenitors in a Subgroup of Children With Chronic Neutropenia Associated With Severe Infections and Delayed Recovery
|
---|---|
Autor/in / Beteiligte Person: | Vivalda, Laura ; Garelli, Emanuela ; Maria Giuseppina Stillitano ; Doria, Alessandra ; Ramenghi, Ugo ; Crescenzio, Nicoletta ; Timeus, Fabio ; Saracco, Paola ; Foglia, Luiselda ; Vallero, Stefano ; Mazzone, Raffaela |
Link: | |
Zeitschrift: | PLoS ONE, Jg. 14 (2019), Heft 3, p e0213782 |
Veröffentlichung: | 2019 |
Medientyp: | unknown |
Schlagwort: |
|
Sonstiges: |
|