The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions
In: Journal of Bacteriology, 187(6), 2010-2019. AMER SOC MICROBIOLOGY; (2005-03-01)
Online
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Zugriff:
Rok is a repressor of the transcriptional activator ComK and is therefore an important regulator of competence in Bacillus subtilis (T. T. Hoa, P. Tortosa, M. Albano, and D. Dubnau, Mol. Microbiol. 43:15-26, 2002). To address the wider role of Rok in the physiology of B. subtilis , we have used a combination of transcriptional profiling, gel shift experiments, and the analysis of lacZ fusions. We demonstrate that Rok is a repressor of a family of genes that specify membrane-localized and secreted proteins, including a number of genes that encode products with antibiotic activity. We present evidence for the recent introduction of rok into the B. subtilis-Bacillus licheniformis-Bacilllus amyloliquefaciens group by horizontal transmission.
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The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions
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| Autor/in / Beteiligte Person: | Albano, M ; Smits, WK ; Ho, LTY ; Kraigher, B ; Mandic-Mulec, [No Value] ; Kuipers, OP ; Dubnau, D ; Smits, Wiep Klaas ; Ho, Linh T.Y. ; Mandic-Mulec, Ines ; Groningen Biomolecular Sciences and Biotechnology ; Genetics, Molecular ; Faculty of Science and Engineering |
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| Quelle: | Journal of Bacteriology, 187(6), 2010-2019. AMER SOC MICROBIOLOGY; (2005-03-01) |
| Veröffentlichung: | 2005 |
| Medientyp: | unknown |
| ISSN: | 0021-9193 (print) |
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