Correlation between Inflammatory Biomarkers and Red Blood Cell Life Span in Chronic Hemodialysis Patients
In: Blood purification, Jg. 43 (2017-01-24), Heft 1-3
Online
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Zugriff:
Background and Objectives: The pathogenesis of anemia in hemodialysis (HD) patients is dependent on multiple factors, with decreased red blood cell life span (RBCLS) being a significant contributor. Although the impact of reduced RBCLS on anemia is recognized, it is still a subject that is not well researched. The objective of this study was to investigate the relationship between RBCLS and inflammatory biomarkers in chronic HD patients. Design, Setting, Participants, and Measurements: RBCLS was calculated from alveolar carbon monoxide concentrations measured by gas chromatography. Interleukins (IL) IL-6, IL-18, IL-10, and high sensitivity C-reactive protein were measured using bead-based multiplex assay. Measurements were carried out at baseline and during follow-up. The associations between RBCLS and inflammatory biomarkers were evaluated using linear mixed effects models. Results: RBCLS measurements were available for 54 HD patients. Their average age was 58.5 ± 14.4 years, 68.5% were males, 48.1% were diabetics, and the HD vintage was 51 ± 48 months. In 4 patients, RBCLS was measured once, while in 50 patients, up to 5 repeated RBCLS measurements were available. RBCLS was 73.2 ± 17.8 days (range 37.7-115.8 days). No association was found between RBCLS and any of the inflammatory biomarkers. Of note, RBCLS was positively correlated with levels of uric acid (p = 0.02) and blood urea nitrogen (BUN; p = 0.01), respectively. Conclusion: Our study suggests that inflammation pathways reported by these biomarkers only have a limited role in causing premature RBC death. The positive correlation with uric acid and BUN warrants further studies.
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Correlation between Inflammatory Biomarkers and Red Blood Cell Life Span in Chronic Hemodialysis Patients
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Autor/in / Beteiligte Person: | Persic, Vanja ; Levin, Nathan W. ; Rosales, Laura ; Ma, Jie ; Williams, Schantel ; Zhang, Hanjie ; Kotanko, Peter ; Ouellet, Georges ; Michelle M.Y. Wong ; Wang, Yuedong ; Dou, Yanna ; Thijssen, Stephan ; Kruse, Anja ; Kuntsevich, Viktoriya |
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Zeitschrift: | Blood purification, Jg. 43 (2017-01-24), Heft 1-3 |
Veröffentlichung: | 2017 |
Medientyp: | unknown |
ISSN: | 1421-9735 (print) |
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