Congenital Cytomegalovirus Infection in the Absence of Maternal Cytomegalovirus-IgM Antibodies
In: Fetal Diagnosis and Therapy, Jg. 42 (2017), S. 144-149
Online
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Zugriff:
Background: Congenital cytomegalovirus (cCMV) infections are the most prevalent intrauterine infections worldwide and are the result of maternal primary or non-primary infections. Early maternal primary infections are thought to carry the highest risk of fetal developmental abnormalities as seen by ultrasound; however, non-primary infections may prove equally detrimental. Methods/Results: This case series presents 5 cases with fetal abnormalities detected in the second and third trimester, in which cCMV infection was ruled out due to negative maternal CMV-IgM. Discussion: This series highlights the possible pitfalls in serology interpretation and fetal diagnosis necessary for appropriate parental counseling. Once fetal abnormalities have been confirmed and cCMV is suspected, maternal CMV serostatus and fetal infection should be determined. Maternal CMV serology may be ambiguous; therefore, caution should be exercised when interpreting the results.
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Congenital Cytomegalovirus Infection in the Absence of Maternal Cytomegalovirus-IgM Antibodies
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Autor/in / Beteiligte Person: | Bloeme J van der Knoop ; Tom F.W. Wolfs ; Murk, Jean-Luc ; Johanna I.P. de Vries ; Nijman, Joppe ; Nikkels, Peter G. J. ; Linda S. de Vries ; Gunkel, Julia ; Manten, Gwendolyn T. R. ; Obstetrics and gynaecology ; Amsterdam Reproduction & Development (AR&D) ; Medical Microbiology and Infection Prevention ; AII - Infectious diseases ; AMS - Growth and Development |
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Zeitschrift: | Fetal Diagnosis and Therapy, Jg. 42 (2017), S. 144-149 |
Veröffentlichung: | S. Karger AG, 2017 |
Medientyp: | unknown |
ISSN: | 1421-9964 (print) ; 1015-3837 (print) |
DOI: | 10.1159/000456615 |
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