1,3 Bis (2-chloroethyl)-1-nitrosourea-induced host resistance to syngeneic LSA mouse leukemia
In: Leukemia Research, Jg. 4 (1980), S. 427-435
Online
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Zugriff:
A syngeneic tumor, the LSA lymphoma of C57BL mice, is considered non-antigenic or only weakly antigenic because no host reaction was elicited after repeated exposure of mice to killed tumor. However, easily detectable complete tumor resistance was elicited after 1 or 2 exposures to BCNU and tumor cure. Marked amplification of this host immunity in the BCNU treatment-cured mouse was shown by serial graded exposures to viable tumor grafts, and it was possible to establish virtually complete resistance to further tumor challenge by this method. A lymphoma spleen colony forming assay detected the antigenic properties of the LSA lymphoma in syngeneic C57BL mice. The host resistance state was easily prevented by sublethal irradiation of the mouse with 300 to 400 rad before tumor implantation. Once resistance was established, it was not altered by 450 rad of total body irradiation. These differences indicate a radiosensitive cell for the adaptive immune response and a less radiosensitive (and more complex) mechanism for the established tumor resistant state.
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1,3 Bis (2-chloroethyl)-1-nitrosourea-induced host resistance to syngeneic LSA mouse leukemia
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Autor/in / Beteiligte Person: | Maruyama, Yosh ; Feola, Jose M. |
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Zeitschrift: | Leukemia Research, Jg. 4 (1980), S. 427-435 |
Veröffentlichung: | Elsevier BV, 1980 |
Medientyp: | unknown |
ISSN: | 0145-2126 (print) |
DOI: | 10.1016/0145-2126(80)90025-9 |
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