Associations of high anti-CMV IgG titer with renal function decline and allograft rejection in kidney transplant patients
In: Journal of the Chinese Medical Association : JCMA, Jg. 85 (2021-12-10), Heft 2
Online
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Zugriff:
An anti-cytomegalovirus (CMV) immunoglobulin G (IgG) antibody is produced after primary CMV infection and generally persists after the primary infection. However, it is not well-known about the relationship between anti-CMV IgG titer and outcomes in kidney transplant recipients. We, therefore, aimed to explore the role of anti-CMV IgG titer on the risks of CMV disease development, allograft rejection, renal function decline, and mortality.In a hospital-based study, we identified 179 CMV-seropositive kidney transplant recipients between January 2013 and December 2017. These patients were divided into low and high anti-CMV IgG titer groups, respectively. The cutoff level of anti-CMV IgG titer was determined by receiver operating characteristic curve analysis. The outcomes evaluated included CMV disease, decrease of ≥15% in estimated glomerular filtration rate (eGFR), biopsy-proven allograft rejection, and all-cause mortality.The high anti-CMV IgG titer group (≥846.2 AU/mL) exhibited a higher risk of CMV disease (adjusted hazard ratio [aHR], 3.77; 95% CI, 1.47-9.68; p = 0.006), eGFR decline ≥15% (aHR, 2.00; 95% CI, 1.19-3.35; p = 0.009), and renal allograft rejection (aHR, 2.95; 95% CI, 1.11-7.87; p = 0.030) than the low titer group (846.2 AU/mL).In kidney transplant recipients, a high anti-CMV IgG titer was associated with higher risks for developing CMV disease, undergoing allograft rejection, and eGFR decline.
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Associations of high anti-CMV IgG titer with renal function decline and allograft rejection in kidney transplant patients
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Autor/in / Beteiligte Person: | Chen, Tz-Heng ; Ou, Shuo-Ming ; Tarng, Der-Cherng |
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Zeitschrift: | Journal of the Chinese Medical Association : JCMA, Jg. 85 (2021-12-10), Heft 2 |
Veröffentlichung: | 2021 |
Medientyp: | unknown |
ISSN: | 1728-7731 (print) |
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