Copper(<scp>i</scp>)-catalyzed tandem synthesis of 2-acylquinolines from 2-ethynylanilines and glyoxals
In: Chemical Communications, Jg. 57 (2021), S. 11811-11814
Online
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Zugriff:
An efficient one-step synthesis of 2-acylquinolines using a copper-catalyzed tandem reaction of 2-ethynylanilines with glyoxals in the presence of piperidine has been developed. This new protocol successfully avoids multi-step operation and the use of highly toxic cyanides required in traditional methods, and provides a practical tool for synthetic and pharmaceutical chemists. Various 2-acylquinolines are obtained with perfect regioselectivity in moderate to good yields (up to 86%). The potential synthetic utility of this method is exemplified by a large-scale experiment and synthetic transformation of the products.
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Copper(<scp>i</scp>)-catalyzed tandem synthesis of 2-acylquinolines from 2-ethynylanilines and glyoxals
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Autor/in / Beteiligte Person: | Jia, Jian ; Yu, Mingwu ; Zhao, Ximei ; Liu, Gang ; Wang, Guanghui ; Liu, Xiguang ; Chu, Xiaoxiao |
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Zeitschrift: | Chemical Communications, Jg. 57 (2021), S. 11811-11814 |
Veröffentlichung: | Royal Society of Chemistry (RSC), 2021 |
Medientyp: | unknown |
ISSN: | 1364-548X (print) ; 1359-7345 (print) |
DOI: | 10.1039/d1cc05612c |
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