An easy way to determine bone mineral density and predict pelvic insufficiency fractures in patients treated with radiotherapy for cervical cancer
In: Strahlentherapie und Onkologie, Jg. 197 (2020-10-06), S. 487-493
Online
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Zugriff:
Purpose The aim of this study was to investigate whether bone mineral density (BMD) as measured in planning computed tomographies (CTs) by a new method is a risk factor for pelvic insufficiency fractures (PIF) after radio(chemo)therapy (R(C)T) for cervical cancer. Methods 62 patients with cervical cancer who received definitive or adjuvant radio(chemo)therapy between 2013 and 2017 were reviewed. The PIF were detected on follow-up magntic resonance imaging (MRI). The MRI of the PIF patients was registered to the planning CT and the PIF contoured. On the contralateral side of the fracture, a mirrored structure of the fracture was generated (mPIF). For the whole sacral bone, three lumbar vertebrae, the first and second sacral vertebrae, and the PIF, we analyzed the BMD (mg/cm3), V50Gy, Dmean, and Dmax. Results Out of 62 patients, 6 (9.7%) had a fracture. Two out of the 6 patients had a bilateral fracture with only one of them being symptomatic. PIF patients showed a significantly lower BMD in the sacral and the lumbar vertebrae (p p Conclusion The dose does not seem to have a relevant impact on the incidence of PIF in our patients. One of the predisposing factors for developing PIF after radiotherapy seems to be the low BMD. We presented an easy method to assess the BMD in planning CTs.
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An easy way to determine bone mineral density and predict pelvic insufficiency fractures in patients treated with radiotherapy for cervical cancer
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Autor/in / Beteiligte Person: | Combs, Stephanie E. ; Löffler, Maximilian T. ; Marciana Nona Duma ; Oechsner, Markus ; Kai Joachim Borm ; Kurrumeli, Drilon ; Christine E Brambs ; Weidenbächer, Bianca |
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Zeitschrift: | Strahlentherapie und Onkologie, Jg. 197 (2020-10-06), S. 487-493 |
Veröffentlichung: | Springer Science and Business Media LLC, 2020 |
Medientyp: | unknown |
ISSN: | 1439-099X (print) ; 0179-7158 (print) |
DOI: | 10.1007/s00066-020-01690-0 |
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