INFγ stimulates arginine transport through system y+L in human monocytes
In: FEBS Letters, , Heft 1-3, S. 177-181
Online
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Zugriff:
Freshly isolated human monocytes transport L-arginine mostly through a sodium independent, NEM insensitive pathway inhibited by L-leucine in the presence, but not in the absence of sodium. Interferon-gamma (IFNgamma) stimulates this pathway, identifiable with system y+L, and markedly enhances the expression of SLC7A7, the gene that encodes for system y+L subunit y+LAT1, but not of SLC7A6, that codes for the alternative subunit y+LAT2. System y+ plays a minor role in arginine uptake by monocytes and the expression of system y+-related genes, SLC7A1 and SLC7A2, is not changed by IFNgamma. These results demonstrate that system y+L is sensitive to IFNgamma.
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INFγ stimulates arginine transport through system y+L in human monocytes
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Autor/in / Beteiligte Person: | Bussolati, Ovidio ; Talarico, Enrica ; Bianca Maria Rotoli ; Barilli, Amelia ; Dall'Asta, Valeria ; Sala, Roberto ; Gazzola, Gian C. |
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Zeitschrift: | FEBS Letters, , Heft 1-3, S. 177-181 |
Veröffentlichung: | Federation of European Biochemical Societies. Published by Elsevier B.V. |
Medientyp: | unknown |
ISSN: | 0014-5793 (print) |
DOI: | 10.1016/j.febslet.2004.06.086 |
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