Microelectrode mapping of tonotopic, laminar, and field-specific organization of thalamo-cortical pathway in rat
In: Neuroscience, Jg. 332 (2016-09-01), S. 38-52
Online
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Zugriff:
The rat has long been considered an important model system for studying neural mechanisms of auditory perception and learning, and particularly mechanisms involving auditory thalamo-cortical processing. However, the functional topography of the auditory thalamus, or medial geniculate body (MGB) has not yet been fully characterized in the rat, and the anatomically-defined features of field-specific, layer-specific and tonotopic thalamo-cortical projections have never been confirmed electrophysiologically. In the present study, we have established a novel technique for recording simultaneously from a surface microelectrode array on the auditory cortex, and a depth electrode array across auditory cortical layers and within the MGB, and characterized the rat MGB and thalamo-cortical projections under isoflurane anesthesia. We revealed that the ventral division of the MGB (MGv) exhibited a low–high–low CF gradient and long-short-long latency gradient along the dorsolateral-to-ventromedial axis, suggesting that the rat MGv is divided into two subdivisions. We also demonstrated that microstimulation in the MGv elicited cortical activation in layer-specific, region-specific and tonotopically organized manners. To our knowledge, the present study has provided the first and most compelling electrophysiological confirmation of the anatomical organization of the primary thalamo-cortical pathway in the rat, setting the groundwork for further investigation.
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Microelectrode mapping of tonotopic, laminar, and field-specific organization of thalamo-cortical pathway in rat
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Autor/in / Beteiligte Person: | Kanzaki, Ryohei ; Takahashi, Kazusa ; Tomoyo Isoguchi Shiramatsu ; Noda, Takahiro ; Nakahara, Haruka ; Takahashi, Hirokazu |
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Zeitschrift: | Neuroscience, Jg. 332 (2016-09-01), S. 38-52 |
Veröffentlichung: | Elsevier BV, 2016 |
Medientyp: | unknown |
ISSN: | 0306-4522 (print) |
DOI: | 10.1016/j.neuroscience.2016.06.024 |
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