Functional and immunological characterization of a Duffy binding-like alpha domain from Plasmodium falciparum erythrocyte membrane protein 1 that mediates rosetting
In: Infection and immunity, Jg. 77 (2009-06-24), Heft 9
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Zugriff:
Individuals residing in areas where Plasmodium falciparum malaria is endemic gradually develop clinical immunity with age following repeated infections (17). Passive transfer experiments have shown that immunoglobulin G (IgG) antibodies play a major role in the mechanisms of protection against malaria (9, 10). Naturally acquired IgGs with specificity for variant surface antigens (VSA) expressed on the surfaces of P. falciparum-infected erythrocytes (IE) are believed to contribute to the regulation of parasite densities in a manner that decreases the incidence of clinical disease (4, 13, 15, 19). The most studied VSA, P. falciparum erythrocyte membrane protein 1 (PfEMP1), is a family of large (∼250 to 350 kDa) (2), polymorphic proteins that are encoded in each parasite genome by ∼60 different var genes (12). Switches in var gene expression allow parasites to evade host immunity (18). PfEMP1 mediates the binding of IE to host endothelial cell receptors, to uninfected erythrocytes to mediate rosetting, and to platelets to form clumps of IE enabling sequestration of the parasite at different sites in the host (21). Sequestration in some internal organs has been implicated in progression to severe disease manifestations, such as cerebral and placental malaria (23). PfEMP1 proteins are composed of a variable number of adhesive domains of two types, namely, Duffy binding-like (DBL) domains and cysteine-rich interdomain regions (34). DBL sequences are extremely polymorphic, probably reflecting the intensity of immune pressure on PfEMP1 proteins at the IE surface. Although these domains average
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Functional and immunological characterization of a Duffy binding-like alpha domain from Plasmodium falciparum erythrocyte membrane protein 1 that mediates rosetting
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Autor/in / Beteiligte Person: | Chitnis, Chetan E. ; Mayor, Alfredo ; Srivastava, Anand ; Puyol, Laura ; Pati, Sudhanshu S. ; Bassat, Quique ; Quintó, Llorenç ; Sharma, Surya K. ; Rovira-Vallbona, Eduard ; Chauhan, Virander S. ; Machevo, Sonia ; Mandomando, Inacio ; Alonso, Pedro L. |
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Zeitschrift: | Infection and immunity, Jg. 77 (2009-06-24), Heft 9 |
Veröffentlichung: | 2009 |
Medientyp: | unknown |
ISSN: | 1098-5522 (print) |
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