Global disease burden estimates of respiratory syncytial virus-associated acute respiratory infection in older adults in 2015: A systematic review and meta-analysis
In: The Journal of Infectious Diseases Shi, T, Denouel, A, Tietjen, A K, Campbell, I, Moran, E, Li, X, Campbell, H, Demont, C, Nyawanda, B O, Chu, H Y, Stoszek, S K, Krishnan, A, Openshaw, P & Falsey, A R & Nair, H 2019, ' Global Disease Burden Estimates of Respiratory Syncytial Virus–Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis ', The Journal of Infectious Diseases https://doi.org/10.1093/infdis/jiz059; (2021)
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Zugriff:
Respiratory syncytial virus–associated acute respiratory infection (RSV-ARI) constitutes a substantial disease burden in older adults aged ≥65 years. We aimed to identify all studies worldwide investigating the disease burden of RSV-ARI in this population. We estimated the community incidence, hospitalization rate, and in-hospital case-fatality ratio (hCFR) of RSV-ARI in older adults, stratified by industrialized and developing regions, using data from a systematic review of studies published between January 1996 and April 2018 and 8 unpublished population-based studies. We applied these rate estimates to population estimates for 2015 to calculate the global and regional burdens in older adults with RSV-ARI in the community and in hospitals for that year. We estimated the number of in-hospital deaths due to RSV-ARI by combining hCFR data with hospital admission estimates from hospital-based studies. In 2015, there were about 1.5 million episodes (95% confidence interval [CI], .3 million–6.9 million) of RSV-ARI in older adults in industrialized countries (data for developing countries were missing), and of these, approximately 14.5% (214 000 episodes; 95% CI, 100 000–459 000) were admitted to hospitals. The global number of hospital admissions for RSV-ARI in older adults was estimated at 336 000 hospitalizations (uncertainty range [UR], 186 000–614 000). We further estimated about 14 000 in-hospital deaths (UR, 5000–50 000) related to RSV-ARI globally. The hospital admission rate and hCFR were higher for those aged ≥65 years than for those aged 50–64 years. The disease burden of RSV-ARI among older adults is substantial, with limited data from developing countries. Appropriate prevention and management strategies are needed to reduce this burden.
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Global disease burden estimates of respiratory syncytial virus-associated acute respiratory infection in older adults in 2015: A systematic review and meta-analysis
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Autor/in / Beteiligte Person: | Shi, Ting ; Denouel, Angeline ; Tietjen, Anna K ; Campbell, Iain ; Moran, Emily ; Li, Xue ; Campbell, Harry ; Demont, Clarisse ; Nyawanda, Bryan O ; Chu, Helen Y ; Stoszek, Sonia K ; Krishnan, Anand ; Openshaw, Peter ; Falsey, Ann R ; Nair, Harish ; Zhang, Shanshan ; Li, You ; Wedzicha, Jadwicha ; Falsey, Ann ; Miller, Mark ; Beutels, Philippe ; Bont, Louis ; Pollard, Andrew ; Molero, Eva ; Martinon-Torres, Federico ; Heikkinen, Terho ; Meijer, Adam ; Fischer, Thea Kølsen ; van den Berge, Maarten ; Giaquinto, Carlo ; Mikolajczyk, Rafael ; Hackett, Judy ; Cai, Bing ; Knirsch, Charles ; Leach, Amanda ; Gallichan, Scott ; Kieffer, Alexia ; Cheret, Arnaud ; Gavart, Sandra ; Aerssens, Jeroen ; Fuentes, Robert ; Rosen, Brian |
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Quelle: | The Journal of Infectious Diseases Shi, T, Denouel, A, Tietjen, A K, Campbell, I, Moran, E, Li, X, Campbell, H, Demont, C, Nyawanda, B O, Chu, H Y, Stoszek, S K, Krishnan, A, Openshaw, P & Falsey, A R & Nair, H 2019, ' Global Disease Burden Estimates of Respiratory Syncytial Virus–Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis ', The Journal of Infectious Diseases https://doi.org/10.1093/infdis/jiz059; (2021) |
Veröffentlichung: | Oxford University Press, 2021 |
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