The angiogenic activity of the fibroblast and epidermal growth factor
In: Experimental Eye Research, Jg. 28 (1979-05-01), S. 501-514
Online
unknown
Zugriff:
The angiogenic activities of the fibroblast and epidermal growth factors in vivo have been analyzed using the rabbit cornea as a model. The angiogenic activity of slow-release form of Elwax 40 containing either fibroblast growth factor (FGF) or epidermal growth factor (EGF) at concentrations ranging from 0·5 to 60 μg were compared. A positive response was observed with concentrations of EGF as low as 1 μg per implant. The optimal concentration causing neovascularization in 100% of the cases was 10 μg per implant. With FGF, a positive response was observed at 2·5 μg per implant and the optimal concentration causing neovascularization in 100% of the cases was 25 μg per implant. In both cases, and in contrast with implants of serum albumin, the neovascularization could be seen to progress in the absence of inflammation.
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The angiogenic activity of the fibroblast and epidermal growth factor
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Autor/in / Beteiligte Person: | Bialecki, H. ; Thakral, T.K. ; Gospodarowicz, Denis |
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Zeitschrift: | Experimental Eye Research, Jg. 28 (1979-05-01), S. 501-514 |
Veröffentlichung: | Elsevier BV, 1979 |
Medientyp: | unknown |
ISSN: | 0014-4835 (print) |
DOI: | 10.1016/0014-4835(79)90038-1 |
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