Clinical applications of analysis of plasma circulating complete hydatidiform mole pregnancy-associated miRNAs in gestational trophoblastic neoplasia: A preliminary investigation
In: Placenta, Jg. 35 (2014-09-01), S. 787-789
Online
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Zugriff:
The aim of this study was to investigate the clinical application of plasma complete hydatidiform mole pregnancy-associated microRNAs (CHM-miRNAs: hsa-miR-520b, hsa-miR-520f and hsa-miR-520c-3p). We measured plasma CHM-miRNA concentration by real-time quantitative reverse transcriptase polymerase chain reaction in two cases of CHM resulting in gestational trophoblastic neoplasia later. As progress of treatments in both cases, the plasma concentrations of CHM-miRNAs showed a decreasing tendency similar to the pattern for serum hCG concentration, but exhibited a transient increasing tendency after each course of chemotherapy, suggesting that the plasma CHM-miRNAs could be an additional follow-up marker for malignant changes of CHM.
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Clinical applications of analysis of plasma circulating complete hydatidiform mole pregnancy-associated miRNAs in gestational trophoblastic neoplasia: A preliminary investigation
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Autor/in / Beteiligte Person: | Kaneuchi, Masanori ; Mishima, Hiroyuki ; Hasegawa, Yuri ; Higashijima, Ai ; Kinoshita, Akira ; Yoshiura, Koh-ichiro ; Miura, Kiyonori ; Abe, Syuhei ; Masuzaki, Hideaki ; Miura, Shiro |
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Zeitschrift: | Placenta, Jg. 35 (2014-09-01), S. 787-789 |
Veröffentlichung: | Elsevier BV, 2014 |
Medientyp: | unknown |
ISSN: | 0143-4004 (print) |
DOI: | 10.1016/j.placenta.2014.06.004 |
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